| Gene Symbol | NME8 |
| Protein Type | Kinase |
| Function | encodes a protein with nucleoside diphosphate kinase (NDPK) activity and a thioredoxin domain |
| Primary Expression | the retina and olfactory bulb, consistent with its role in ciliary function |
| UniProt ID | Q9NPJ3 |
| Ensembl ID | ENSG00000186919 |
| GeneCards | NME8 |
| Human Protein Atlas | NME8 |
| NDPK Domain | Nucleoside diphosphate kinase activity |
| Thioredoxin Domain | Oxidoreductase activity |
| Ciliary/Flagellar Function | Essential for sperm motility and respiratory cilia |
| NDPK Activity | Maintains nucleotide pools for DNA/RNA synthesis |
| Thioredoxin Activity | Antioxidant function, maintaining cellular redox balance |
| Microtubule Regulation | Involved in microtubule organization |
| Protein Thiol-Disulfide Oxidoreductase | Catalyzes disulfide bond formation/reduction |
| Associated Diseases | Als, Alzheimer, Ms |
| Interactions | ABCA7, APOE, BIN1, CASS4, CD2AP, CD33 |
| KG Connections | 72 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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