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gene 2,484 words KG: EPHA1
Contents

EPHA1 Gene

🧬 Gene Info
Gene SymbolEPHA1
Full NameEphrin Type-A Receptor 1
Chromosome7q34
Protein TypeReceptor
FunctionReceptor Tyrosine Kinase Function: Binds ephrin-A ligands to initiate bidirectional signaling
Primary ExpressionNeurons, Astrocytes, Microglia, T-cells
Molecular Weight108 kDa
Amino Acids976 aa
Exons18
UniProt IDP21709
NCBI Gene ID2043
Ensembl IDENSG00000146938
OMIM179610
GeneCardsEPHA1
Human Protein AtlasEPHA1
Associated DiseasesAls, Alzheimer, Alzheimer's disease, COGNITIVE DECLINE, Inflammation, Ms
InteractionsABCA7, AD, ALZHEIMER, ALZHEIMER'S DISEASE, APOE, App
KG Connections171 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

ABCA7 (Redirect)
redirect · KG edge: activatesBIN1 — Bridging Integrator 1
gene · KG edge: activatesCASS4 — Cas Scaffold Protein Family Member 4
gene · KG edge: activatesCD2AP Gene — CD2-Associated Protein
gene · KG edge: activatesAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

PLD3 associated_with EPHA1
ABCA7 associated_with EPHA1
SORL1 associated_with EPHA1
PICALM associated_with EPHA1
CR1 associated_with EPHA1
TREM2 associated_with EPHA1
CASS4 associated_with EPHA1
CD33 associated_with EPHA1
NME8 associated_with EPHA1
BIN1 associated_with EPHA1

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