gene 608 words KG: RELA
Contents

RELA (NF-κB p65)

🧬 Gene Info
Gene SymbolNF
Full NameκB p65 Protein
AliasesNF-κB p65
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight65 kDa
PathwaysNF-κB, NF-κB signaling
UniProt ID[P06579](https://www.uniprot.org/uniprot/P06579)
GeneCardsNF
Human Protein AtlasNF
RELA (p65)Primary transcriptional activator
REL (c-Rel)Lymphoid-specific subunit
RELBInducible subunit
NF-κB1 (p50/p105)Constitutive subunit
Associated DiseasesAging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/CompoundsRESVERATROL
InteractionsAKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections750 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (196)

Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
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Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
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Membrane Cholesterol Gradient Modulators
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Orexin-Microglia Modulation Therapy
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TET2-Mediated Demethylation Rejuvenation Therapy
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Lysosomal Enzyme Trafficking Correction
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
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Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
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Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
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CRISPR-based therapeutic approaches for neurodegenerative di
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Tau propagation mechanisms and therapeutic interception poin
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See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: co_discussed
ABCG1 Gene
gene · KG edge: co_discussed
ACTB Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

NRF2 inhibits RELA
P38 activates RELA
IL1B activates RELA
PRDX1 activates RELA
TRAF6 activates RELA
CHUK activates RELA
PRDX6 activates RELA
MAPK14 activates RELA
BECN1 activates RELA
TNF activates RELA

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