gene 608 words KG: RELA
Contents

RELA (NF-κB p65)

🧬 Gene Info
Gene SymbolNF
Full NameκB p65 Protein
AliasesNF-κB p65
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight65 kDa
PathwaysNF-κB, NF-κB signaling
UniProt ID[P06579](https://www.uniprot.org/uniprot/P06579)
GeneCardsNF
Human Protein AtlasNF
RELA (p65)Primary transcriptional activator
REL (c-Rel)Lymphoid-specific subunit
RELBInducible subunit
NF-κB1 (p50/p105)Constitutive subunit
Associated DiseasesAging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/CompoundsRESVERATROL
InteractionsAKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections750 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (196)

Phase-Separated Organelle Targeting
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
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Metabolic Switch Targeting for A1→A2 Repolarization
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TFAM overexpression creates mitochondrial donor-recipient gr
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Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Purinergic Signaling Polarization Control
Score: 0.71
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
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Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: co_discussed
ABCG1 Gene
gene · KG edge: co_discussed
ACTB Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

NRF2 inhibits RELA
P38 activates RELA
IL1B activates RELA
PRDX1 activates RELA
TRAF6 activates RELA
CHUK activates RELA
PRDX6 activates RELA
MAPK14 activates RELA
BECN1 activates RELA
TNF activates RELA

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