gene 608 words KG: RELA
Contents

RELA (NF-κB p65)

🧬 Gene Info
Gene SymbolNF
Full NameκB p65 Protein
AliasesNF-κB p65
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight65 kDa
PathwaysNF-κB, NF-κB signaling
UniProt ID[P06579](https://www.uniprot.org/uniprot/P06579)
GeneCardsNF
Human Protein AtlasNF
RELA (p65)Primary transcriptional activator
REL (c-Rel)Lymphoid-specific subunit
RELBInducible subunit
NF-κB1 (p50/p105)Constitutive subunit
Associated DiseasesAging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/CompoundsRESVERATROL
InteractionsAKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections755 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (196)

Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Cryptic Exon Silencing Restoration
Score: 0.53
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Synthetic Biology Approach: Designer Mitochondrial Export Sy
Score: 0.51
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
← Prevpg 10/10

Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: co_discussed
ABCG1 Gene
gene · KG edge: co_discussed
ACTB Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

NRF2 inhibits RELA
P38 activates RELA
IL1B activates RELA
PRDX1 activates RELA
TRAF6 activates RELA
CHUK activates RELA
PRDX6 activates RELA
MAPK14 activates RELA
BECN1 activates RELA
TNF activates RELA

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