gene 1,621 words KG: PPARG
Contents

PPARG — Peroxisome Proliferator-Activated Receptor Gamma

🧬 Gene Info
Gene SymbolPPARG
Full NamePeroxisome Proliferator-Activated Receptor Gamma
Chromosome3p25.2.
Protein TypeReceptor
Functionis a member of the nuclear receptor superfamily of ligand-activated transcription factors.
Primary Expressionneurons, astrocytes, and microglia, where it modulates neuroinflammation, mitochondrial function, synaptic plasticity, and cellular survival
Molecular Weight56 kDa
Amino Acids505 aa
Exons9
PathwaysAkt, Apoptosis, Autophagy, Cholesterol, Glycolysis
Ensembl IDENSG00000132170
GeneCardsPPARG
Human Protein AtlasPPARG
Alternative promotersDistinct TSS for PPARG1 and PPARG2
Epigenetic controlCpG island in promoter region
Associated DiseasesAD, ADH, Als, Alzheimer, AMI
Known Drugs/CompoundsAbscisic acid, Betulinic Acid, Bezafibrate, endogenous ligands, GW9662, ibuprofen
InteractionsACETYL-COA, Actin, AGING, AKT, AKT1, AKT1S1
KG Connections1183 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (34)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
← Prevpg 2/2

Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
ALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

ACTB regulates PPARG
PPARA regulates PPARG
CAT regulates PPARG
SQSTM1 regulates PPARG
RPS6KB1 regulates PPARG
RAB7A regulates PPARG
SREBF1 regulates PPARG
EIF4EBP1 regulates PPARG
CTSD regulates PPARG
PPARGC1A regulates PPARG

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