gene 1,621 words KG: PPARG
Contents

PPARG — Peroxisome Proliferator-Activated Receptor Gamma

🧬 Gene Info
Gene SymbolPPARG
Full NamePeroxisome Proliferator-Activated Receptor Gamma
Chromosome3p25.2.
Protein TypeReceptor
Functionis a member of the nuclear receptor superfamily of ligand-activated transcription factors.
Primary Expressionneurons, astrocytes, and microglia, where it modulates neuroinflammation, mitochondrial function, synaptic plasticity, and cellular survival
Molecular Weight56 kDa
Amino Acids505 aa
Exons9
PathwaysAkt, Apoptosis, Autophagy, Cholesterol, Glycolysis
Ensembl IDENSG00000132170
GeneCardsPPARG
Human Protein AtlasPPARG
Alternative promotersDistinct TSS for PPARG1 and PPARG2
Epigenetic controlCpG island in promoter region
Associated DiseasesAD, ADH, Als, Alzheimer, AMI
Known Drugs/CompoundsAbscisic acid, Betulinic Acid, Bezafibrate, endogenous ligands, GW9662, ibuprofen
InteractionsACETYL-COA, Actin, AGING, AKT, AKT1, AKT1S1
KG Connections1183 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (34)

HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
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Related Analyses (14)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
ALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

ACTB regulates PPARG
PPARA regulates PPARG
CAT regulates PPARG
SQSTM1 regulates PPARG
RPS6KB1 regulates PPARG
RAB7A regulates PPARG
SREBF1 regulates PPARG
EIF4EBP1 regulates PPARG
CTSD regulates PPARG
PPARGC1A regulates PPARG

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