gene 1,083 words KG: GLUD1
Contents

GLUD1 - Glutamate Dehydrogenase 1

🧬 Gene Info
Gene SymbolGLUD1
Full NameGlutamate Dehydrogenase 1
AliasesPage for GLUD1
Chromosome10q23.3
Protein TypeEnzyme
FunctionGLUD1 is a mitochondrial matrix enzyme belonging to the glutamate dehydrogenase family
Primary ExpressionLiver, kidney, brain, pancreas
Amino Acids505 aa
PathwaysGlycolysis, Histone Modification, Mtor, Oxidative Phosphorylation, Oxidative Stress
UniProt ID[P00341](https://www.uniprot.org/uniprot/P00341)
Ensembl IDENSG00000148671
OMIM130120
GeneCardsGLUD1
Human Protein AtlasGLUD1
N-terminal antenna regionContains the allosteric binding sites
Associated DiseasesParkinson, Parkinson'S Disease
InteractionsACO2, ANXIETY, ATP, AUTOPHAGY, BECN1, CANCER
KG Connections118 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Levodopa-Induced Dyskinesias Mechanism — Experiment Design
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (13)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
Genes
index · KG edge: inhibits
ACO2 — Aconitase 2
gene · KG edge: activates
BECN1 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

SQSTM1 inhibits GLUD1
MAP1LC3B inhibits GLUD1
GRID1 interacts_with GLUD1
GLUD1 inhibits LAMP1
GLUD1 inhibits PRKCD
GLUD1 interacts_with CBLN1
GLUD1 inhibits BECN1
PRKCD inhibits GLUD1
LAMP1 inhibits GLUD1
CBLN1 interacts_with GLUD1

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