gene 529 words KG: PANX1
Contents

PANX1 Gene

🧬 Gene Info
Gene SymbolPANX1
Full NamePannexin 1
Chromosome11q14.2
Protein FamilyPannexin family
Protein TypeChannel
Functionis a channel-forming protein that releases ATP and other signaling molecules from cells.
Subcellular LocalizationPlasma membrane, endoplasmic reticulum
Molecular Weight1 kDa
Amino Acids426 aa
PathwaysLIPID METABOLISM, Lipid Metabolism, apoptosis pathway, lipid metabolism, mitochondrial function
UniProt IDQ96HY7
NCBI Gene ID9399
Ensembl IDENSG00000110234
OMIM608421
GeneCardsPANX1
Human Protein AtlasPANX1
Associated DiseasesAls, Alzheimer, Inflammation, neurodegeneration, neuroinflammation
InteractionsActin, adora2b, ADORA2B, AND, F3, GENES
SciDEX HypothesesGap Junction Hemichannel Modulation for Controlled
KG Connections144 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.44
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (6)

Mitochondrial transfer between neurons and glia
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: associated_with
nad-augmentation-therapy-early-ad
general · KG edge: associated_with
Genes
index · KG edge: activates
ADORA2B Gene
gene · KG edge: activates
BNIP3 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

ADORA2B activates PANX1
P2RY12 activates PANX1
P2RX1 activates PANX1
P2RX4 activates PANX1
P2RX7 activates PANX1
CD38 associated_with PANX1
P2RY1 activates PANX1
P2RX5 activates PANX1
PANX1 activates P2X7
PANX1 activates SRC

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