gene 758 words KG: P2RX4
Contents

P2RX4 Gene

🧬 Gene Info
Gene SymbolP2RX4
Full NamePurinergic Receptor P2X 4
Chromosome12q24.31
FunctionThe P2RX4 gene encodes the P2X4 receptor subunit, which forms homomeric and heteromeric ion channels permeable to Na⁺, K⁺, and Ca²⁺.
Primary ExpressionBrain, Spinal Cord, Microglia, Astrocytes
PathwaysGlucose Homeostasis
UniProt IDQ99572
NCBI Gene ID10065
GeneCardsP2RX4
Human Protein AtlasP2RX4
Associated DiseasesAls, DIABETES, glycemic traits, Inflammation, Ms
Interactionsadora2b, ADORA2B, AND, F3, GENES, P2RX1
KG Connections101 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
P2RX7 variant rs1718119 association with glucose homeostasis
exploratory · proposed · Score: 0.90

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: associated_with
nad-augmentation-therapy-early-ad
general · KG edge: associated_with
Genes
index · KG edge: activates
ADORA2B Gene
gene · KG edge: activates
CAMKK2 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

P2RX1 therapeutic_target P2RX4
P2RX4 therapeutic_target P2RX7
P2RX4 therapeutic_target P2RY14
P2RX4 therapeutic_target P2RY1
ADORA2B activates P2RX4
P2RY12 activates P2RX4
P2RX1 activates P2RX4
P2RX4 activates P2RX7
P2RX4 associated_with CD38
P2RX4 activates P2RY1

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