gene 1,202 words KG: MAP1LC3B
Contents

MAP1LC3B — LC3B

🧬 Gene Info
Gene SymbolMAP1LC3B
Full NameMicrotubule-Associated Protein 1 Light Chain 3 Beta (LC3B)
AliasesLC3B
Chromosome16q24.2
FunctionMAP1LC3B encodes LC3B, a key protein in the autophagy pathway.
Primary ExpressionUbiquitous, high in brain (neurons and glia), liver, heart, skeletal muscle
Molecular Weight14.5 kDa
Amino Acids125 aa
PathwaysApoptosis, Autophagy, Immune Response, Innate Immunity, Mapk
UniProt IDQ9GZQ8
NCBI Gene ID81631
Ensembl IDENSG00000140941
OMIM609605
GeneCardsMAP1LC3B
Human Protein AtlasMAP1LC3B
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundscocaine, LPS, rapamycin
InteractionsABCD3, ACTB, AGING, AIF1, AIFM1, ALOX
KG Connections1964 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (30)

Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Cryptic Exon Silencing Restoration
Score: 0.53
← Prevpg 2/2

Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (11)

Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (6)

ABCD3 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates
AIF1 Gene
gene · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed

Knowledge Graph (12 edges)

ACTB regulates MAP1LC3B
PPARA regulates MAP1LC3B
CAT regulates MAP1LC3B
SQSTM1 regulates MAP1LC3B
RPS6KB1 regulates MAP1LC3B
RAB7A regulates MAP1LC3B
SREBF1 regulates MAP1LC3B
EIF4EBP1 regulates MAP1LC3B
CTSD regulates MAP1LC3B
PPARGC1A regulates MAP1LC3B

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