| Gene Symbol | ANO1 |
| Aliases | Anoctamin 1 (TMEM16A |
| Chromosome | 11q13 |
| Protein Family | Anoctamin/TMEM16 |
| Protein Type | Channel |
| Function | This channel is distinct from voltage-gated chloride channels (CLCNs) and represents a major pathway for calcium-dependent chloride conductance in epithelial and neuronal cells[@hartmann2022]. |
| Primary Expression | various tissues, including the gastrointestinal tract, respiratory epithelium, and sensory neurons |
| GeneCards | ANO1 |
| Human Protein Atlas | ANO1 |
| Olfactory bulb | involved in olfactory signal processing |
| Cortical neurons | contributes to neuronal excitability |
| Sensory neurons | particularly in dorsal root ganglion (DRG) neurons |
| Substantia nigra | region affected in Parkinson's disease[@patteson2021] |
| Associated Diseases | Neurodegeneration, Alzheimer's disease pathogenesis through several mechanisms, Parkinson's disease |
| Interactions | AKT, CTNNB1, EGFR, PI3K |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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