gene 1,625 words KG: CDKN2A
Contents

CDKN2A Gene

🧬 Gene Info
Gene SymbolCDKN2A
Chromosome9p21.3
Functionis a 156-amino acid protein composed of ankyrin repeat domains that adopt a highly twisted, left-handed helix structure[@li2019].
Molecular Weight16 kDa
Amino Acids156 aa
PathwaysGlycolysis, Tgf-Β
UniProt IDP42771
NCBI Gene ID1029
Ensembl IDENSG00000147883
GeneCardsCDKN2A
Human Protein AtlasCDKN2A
p12^INK4a^Alternatively spliced variant with truncated N-terminus
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsAGING, AKT, AKT3, AND, APC, APOPTOSIS
SciDEX HypothesesHippocampal-Cortical Transcriptomic Divergence Rev
Senescence-Tau Decoupling Therapy
KG Connections457 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67

Related Analyses (6)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
APC Gene
gene · KG edge: activates
ARID1A
gene · KG edge: activates
ATM Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CDKN2A inhibits cell cycle progression
FGFR1 therapeutic_target CDKN2A
SOX2 therapeutic_target CDKN2A
CDK4 inhibits CDKN2A
RB1 inhibits CDKN2A
CDKN2A therapeutic_target EZH2
CDKN2A therapeutic_target NSD3
PTEN associated_with CDKN2A
EGR4 associated_with CDKN2A
EGFR associated_with CDKN2A

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