| Gene Symbol | NSD3 |
| Full Name | Nuclear Receptor Binding SET Domain Protein 3 |
| Chromosome | 8p11.23 |
| Protein Type | Transferase |
| Function | encodes a histone lysine methyltransferase of the nuclear receptor SET domain (NSD) family that catalyzes mono- and dimethylation of histone H3 at lysine 36 (H3K36me1/2). |
| Amino Acids | 1437 aa |
| Pathways | Epigenetic |
| UniProt ID | [Q9BZ95](https://www.uniprot.org/uniprot/Q9BZ95) |
| Ensembl ID | ENSG00000147548 |
| GeneCards | NSD3 |
| Human Protein Atlas | NSD3 |
| SET domain | Catalytic methyltransferase domain for H3K36 methylation |
| PWWP domain | Chromatin reader module that recognizes H3K36me marks and mediates chromatin targeting |
| PHD fingers (2x) | Zinc finger domains that bind histone tails and mediate protein–protein interactions |
| Nuclear receptor interaction domain | Enables interactions with nuclear hormone receptors and transcription factor complexes |
| Associated Diseases | neurodegeneration |
| Interactions | HK2, MYC, PPP1CB, STAT3 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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