concept

C1Q/C3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1Q/C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

160Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

1Debates

Summary

C1Q/C3 is a concept in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with Aging, Anxiety, Depression. Connected to 56 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	C1Q/C3
Key Genes/Proteins	AGING, AKT, ALS, AND, ANXIETY, AQP4
Related Diseases	Aging, Als, Anxiety
Related Pathways	Akt, Autophagy

Pathway Diagram

graph TD
    C1Q_C3["C1Q/C3"]
    C1Q_C3 -->|"causes"| Anxiety["Anxiety"]
    C1Q_C3 -->|"causes"| Aging["Aging"]
    C1Q_C3 -->|"regulates"| Depression["Depression"]
    C1Q_C3 -->|"inhibits"| RAB11["RAB11"]
    C1Q_C3 -->|"inhibits"| COMPLEMENT["COMPLEMENT"]
    C1Q_C3 -->|"inhibits"| C1Q["C1Q"]
    C1Q_C3 -->|"inhibits"| Complement["Complement"]
    C1Q_C3 -->|"inhibits"| Phagocytosis["Phagocytosis"]
    C1Q_C3 -->|"inhibits"| RAB5["RAB5"]
    RAB5 -->|"inhibits"| C1Q_C3
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| C1Q_C3
    COMPLEMENT -->|"regulates"| C1Q_C3
    C1Q -->|"inhibits"| C1Q_C3
    ANXIETY["ANXIETY"] -->|"causes"| C1Q_C3
    MICROGLIA["MICROGLIA"] -->|"inhibits"| C1Q_C3
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"causes"| C1Q_C3
    DEPRESSION["DEPRESSION"] -->|"regulates"| C1Q_C3
    AND["AND"] -->|"inhibits"| C1Q_C3

Outgoing (95)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.67
Depression	regulates	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Aging	causes	disease	0.65
Depression	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Anxiety	causes	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Ftd	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
MICROGLIA	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
PI3K	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
ELAVL2	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
C1Q	inhibits	gene	0.60
CLPP	associated_with	gene	0.60
C1Q	activates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	inhibits	gene	0.60
AGING	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Complement	inhibits	pathway	0.60
COMPLEMENT	regulates	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
Complement	therapeutic_target	pathway	0.60
Phagocytosis	therapeutic_target	pathway	0.60
BDNF	associated_with	gene	0.60
RAB11	inhibits	gene	0.60
PI3K	associated_with	gene	0.60

Incoming (65)

Source	Relation	Type	Str
LYSOSOME	associated_with	gene	0.60
PHAGOCYTOSIS	inhibits	gene	0.60
COMPLEMENT	regulates	gene	0.60
ANXIETY	causes	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
DEPRESSION	regulates	gene	0.60
AGING	associated_with	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
RNA	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
YTHDF1	associated_with	gene	0.60
COMPLEMENT	inhibits	gene	0.60
WNT	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
C1Q	mediates	entity	0.60
C1Q	activates	entity	0.60
C1Q	downregulates	entity	0.60
C1Q	therapeutic_target	entity	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
COMPLEMENT	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
C1Q	inhibits	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	inhibits	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
IGF2BP1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
AKT	associated_with	gene	0.60
FUS	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
RAB11	inhibits	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.910	neurodegeneration	Senolytic therapy for age-related neurod
Excessive C1q/C3/CR3 complement cascade activation initiates	0.720	neurodegeneration	Synaptic pruning by microglia in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Alzheimer's Disease	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
Experiment: Autoimmune Hypothesis Testing in AD	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated Neurotoxic	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000
Microglial Aging and Immune Memory in Neurodegeneration — Training the	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,960,000
Microglial Contributions to Huntington's Disease Pathogenesis	validation	Neuroinflammation	0.400	0.50	human	proposed	$2,960,000
Mixed Pathology Effects on Parkinson's Disease Progression and Treatme	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021]	Xie M, Feng L, Li R, Li M, Shen L, Zhang	CNS neuroscience & therapeutic	2026	0
Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756]	Perez-Toledo M, Aksu-Istil K, Marcial-Ju	mBio	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448]	Taxiarchis A, Pruner I	Current opinion in hematology	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of [PMID:39947489]	Zhao Q, Zeng C, Luo F, Xian Z, Wen H, Tu	Brain, behavior, and immunity	2025	0
Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflamma [PMID:38342616]	Ambrin G, Kang YJ, Van Do K, Lee C, Sing	Advanced science (Weinheim, Ba	2024	0
Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789]	["Zhu J", "Wei R", "Hu G", "Wang H", "Wa	Small (Weinheim an der Bergstr	2024	0
The Role of Complement Dysregulation in Glaucoma. [PMID:38396986]	["Hoppe C", "Gregory-Ksander M"]	International journal of molec	2024	0
Retracted: Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury v [PMID:38234567]	["Longevity O"]	Oxidative medicine and cellula	2024	0
Divergent complement system activation in two clinically distinct murine models [PMID:35958570]	["Linzey M", "DiSano K", "Welsh N", "Pac	Frontiers in immunology	2022	0
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheim [PMID:35236834]	Zhao Y, Hu D, Wang R, Sun X, Ropelewski	Nature communications	2022	0
Impact of satellite blood culture on early diagnosis of sepsis. [PMID:36789234]	["Guo Z", "Guo B", "Wang S", "Zhang H",	Journal of intensive medicine	2022	0

Debates (1)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning C1Q/C3 in their description or question text

No additional research found