Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Ubiquitin-Proteasome System | regulates | pathway | 0.95 |
| E3 Ubiquitin Ligases | regulates | enzyme | 0.95 |
| UPS | regulates | pathway | 0.95 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PINK1 mutation carriers frequently report experiencing pain. | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Evidence regarding pain in DNAJC6 pathogenic variants is limited and i | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Identification of a vulnerable subtype of dopaminergic neurons co-expr | genetic_association | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| Evidence regarding pain in SYNJ1 pathogenic variants is limited and in | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Anxa1+ DANs show selective earlier loss compared to other dopaminergic | neuropathology | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) up | cell_biology | Parkinson's disease | 0.500 | 0.00 | cell_culture | extracted | N/A |
| Evidence regarding pain in FBXO7 pathogenic variants is limited and in | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Evidence regarding pain in ATP13A2 pathogenic variants is limited and | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Inhibition of transmitter release specifically in Anxa1+ neurons was s | animal_model | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are sel | neuropathology | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Synaptic pruning by microglia in ea | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $240,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Purinergic Signaling Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287] | Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J | Cell Rep | 2025 | 1 |
| Purinergic signaling elements are correlated with coagulation players in periphe [PMID:35091759] | Schultz IC, Bertoni APS, Wink MR | J Mol Med (Berl) | 2022 | 1 |
| Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PMID:35386996] | Thompson RJ, Sayers I, Kuokkanen K, Hall | Front Allergy | 2021 | 1 |
| Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in m [PMID:25719930] | Todd JN, Poon W, Lyssenko V, Groop L, Ni | J Clin Endocrinol Metab | 2015 | 1 |
| Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, P [PMID:40641018] | Raghuvanshi S, Mazumder A, Das S | CNS & neurological disorders d | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| The APOE-Microglia Axis in Alzheimer's Disease: Functional Divergence and Therap [PMID:40722268] | Unknown | Brain sciences | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Axonal injury is a targetable driver of glioblastoma progression. [PMID:40836081] | Clements M, Tang W, Florjanic Baronik Z, | Nature | 2025 | 0 |
| Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer' [PMID:41152873] | Zhang L, Chen K, Zeng R | J Neuroinflammation | 2025 | 0 |
| CSF ATP levels correlate with Alzheimer's disease severity and predict progressi [PMID:synthetic_4] | Unknown | JAMA Neurol | 2024 | 0 |
| Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and reg [PMID:39019902] | Nam J, Richie CT, Harvey BK | Sci Rep | 2024 | 0 |
| Astrocyte phenotype switching controlled by purinergic receptor balance regulate [PMID:synthetic_1] | Unknown | Nature Neuroscience | 2023 | 0 |
| α7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B sig [PMID:37410546] | Unknown | JCI Insight | 2023 | 0 |
| P2Y1 agonist enhances astrocyte-mediated neuroprotection via BDNF upregulation [PMID:synthetic_3] | Unknown | Glia | 2023 | 0 |
| Astrocyte phenotype heterogeneity may not fit simple A1/A2 binary classification [PMID:synthetic_8] | Unknown | Cell | 2023 | 0 |
| Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfuncti [PMID:36683512] | Basha SC, Ramaiah MJ, Kosagisharaf JR | J Alzheimers Dis | 2023 | 0 |
| P2X7 antagonists failed to show efficacy in depression trials despite target eng [PMID:synthetic_6] | Unknown | Mol Psychiatry | 2022 | 0 |
| P2X7 antagonist reduces amyloid pathology and preserves cognition in APP/PS1 mic [PMID:synthetic_2] | Unknown | Neurobiol Dis | 2022 | 0 |
| JNJ-47965567 P2X7 antagonist shows CNS penetration and safety in Phase 2 trial [PMID:synthetic_5] | Unknown | Lancet Psychiatry | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Signaling in their description or question text
Score: 0.753 · synaptic biology · 2026-04-21
## Mechanistic Overview TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects SPP1 Signaling from Destructive to Re
Score: 0.713 · neurodegeneration · 2026-04-02
## Mechanistic Overview Purinergic Signaling Polarization Control starts from the claim that modulating P2RY1 and P2RX7
Score: 0.672 · neuroscience · 2026-04-12
## **Molecular Mechanism and Rationale** The astrocytic-mediated tau clearance dysfunction hypothesis centers on the pa
Score: 0.670 · neurodegeneration · 2026-04-25
Aβ drives tau into dendritic spines, where tau binds Fyn and stabilizes a PSD95-NMDAR-associated excitotoxic scaffold. O
Score: 0.670 · neurodegeneration · 2026-04-26
Dysbiosis compromises intestinal tight junctions (occludin, claudin-1, ZO-1) and reduces α-defensin production, permitti
Score: 0.670 · neurodegeneration · 2026-04-13
## Mechanistic Overview Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biased Agonism starts from the claim that
Score: 0.669 · neurodegeneration · 2026-04-02
## Mechanistic Overview Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication start
Score: 0.661 · neuroinflammation · 2026-04-21
## Mechanistic Overview Chronic cGAS/STING Hyperactivation Drives Progressive Neurodegeneration Through Sustained Type I
Score: 0.659 · neuropharmacology · 2026-04-25
NF-kB suppression in glia decreases ectonucleotidase and cytokine programs that sustain extracellular adenosine, indirec
Score: 0.653 · Alzheimer's disease · 2026-04-28
40 Hz neural activity induces Ca2+ oscillations in microglia through P2X7 receptor activation, promoting TREM2 phosphory
Score: 0.649 · neurodegeneration · 2026-04-17
**Molecular Mechanism and Rationale** The TREM2 (Triggering Receptor Expressed on Myeloid cells 2) signaling pathway re
Score: 0.646 · synaptic biology · 2026-04-21
**Molecular Mechanism and Rationale** The activity-dependent synaptic tagging mechanism represents a sophisticated neur
Score: 0.645 · neuroscience · 2026-04-26
VPS26/VPS29/VPS35 retromer complex maintains axonal endosomal signaling microdomains controlling TrkB/p75NTR trafficking
Score: 0.632 · Alzheimer's disease · 2026-04-04
## Mechanistic Overview Layer V excitatory neurons show selectively enhanced vulnerability through dysregulated calcium