gene

TREM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

33Outgoing

16Incoming

0Experiments

0Debates

Summary

Page for TREM1 — Triggering Receptor Expressed on Myeloid Cells 1

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🧬 Gene Info

Gene Symbol	TREM1
Full Name	Triggering Receptor Expressed on Myeloid Cells 1
Chromosome	6p21.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	234 aa
Exons	5
Pathways	NF-κB, MAPK pathway
NCBI Gene ID	54206
GeneCards	TREM1
Human Protein Atlas	TREM1
Extracellular domain	V-type immunoglobulin-like domain
Transmembrane domain	Single pass helix
Cytoplasmic tail	Short (5 aa) - signals through adaptor protein DAP12
Associated Diseases	cognitive impairment, neurodegeneration, neuroinflammation
Known Drugs/Compounds	LP17
Interactions	AGING, AUTOPHAGY, CD14, CD33, DAP12, LIPOPHAGY
KG Connections	49 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TREM1 — Triggering Receptor Expressed on Myeloid Cells 1

gene · 707 words

→

TREM1-TREM2 Balanced Microglial Modulation Therapy

idea · 606 words

→

Pathway Diagram

graph TD
    TREM1["TREM1"]
    neuroinflammation["neuroinflammation"]
    TREM1 -->|"causes"| neuroinflammation
    lipophagy(["lipophagy"])
    TREM1 -->|"inhibits"| lipophagy
    NLRP3["NLRP3"]
    TREM1 -->|"activates"| NLRP3
    cognitive_impairment["cognitive impairment"]
    TREM1 -->|"causes"| cognitive_impairment
    Inflammation{"Inflammation"}
    TREM1 -->|"therapeutic target"| Inflammation
    Diabetes{"Diabetes"}
    TREM1 -->|"activates"| Diabetes
    Aging{"Aging"}
    TREM1 -->|"activates"| Aging
    Neuroinflammation{"Neuroinflammation"}
    TREM1 -->|"therapeutic target"| Neuroinflammation
    Inflammasome(["Inflammasome"])
    TREM1 -->|"activates"| Inflammasome
    Autophagy(["Autophagy"])
    TREM1 -->|"activates"| Autophagy
    INFLAMMATION["INFLAMMATION"]
    TREM1 -->|"therapeutic target"| INFLAMMATION
    LIPOPHAGY["LIPOPHAGY"]
    TREM1 -->|"activates"| LIPOPHAGY
    LP17["LP17"]
    LP17 -->|"inhibits"| TREM1
    lipid_droplets["lipid droplets"]
    lipid_droplets -->|"contributes to"| TREM1
    lipid_droplets -->|"associated with"| TREM1
    lipid_droplets -->|"causes"| TREM1
    NLRP3 -->|"activates"| TREM1
    AGING["AGING"]
    AGING -->|"activates"| TREM1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| TREM1
    style TREM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
alzheimer_disease	contributes_to	disease	0.95
microglial_activation	activates	mechanism	0.90
neuroinflammation	causes	phenotype	0.90
lipophagy	inhibits	pathway	0.90
Major Adverse Cardiovascular Events	biomarker_for	phenotype	0.90
mitochondrial_dysfunction	causes	mechanism	0.85
BIOMARKER_FOR	associated_with	unknown	0.80
cognitive impairment	causes	phenotype	0.80
NLRP3	activates	protein	0.80
oxidative_stress	modulates	phenotype	0.75
INFLAMMATION	protects_against	phenotype	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Microglia	regulates	cell_type	0.60
Immune Response	regulates	pathway	0.60
neurodegeneration	associated_with	disease	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
Alzheimer's disease	inhibits	disease	0.60
NF-kB signaling	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
AGING	destabilizes	phenotype	0.60
INFLAMMATION	therapeutic_target	gene	0.60
LIPOPHAGY	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
macrophages	expressed_in	cell_type	0.60
TREM2	inhibits	gene	0.60
Inflammasome	activates	pathway	0.60
Autophagy	activates	pathway	0.60
TREM2	interacts_with	gene	0.55
microglia	expressed_in	cell_type	0.55

Incoming (16)

Source	Relation	Type	Str
LP17	inhibits	drug	0.90
lipid droplets	causes	phenotype	0.80
lipid droplets	associated_with	phenotype	0.80
NLRP3	activates	gene	0.60
DAP12	activates	gene	0.60
DAP12	inhibits	gene	0.60
CD33	inhibits	gene	0.60
NLRP3	associated_with	gene	0.60
TNC	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
PLIN2	interacts_with	gene	0.60
AGING	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CD14	interacts_with	gene	0.55
TLR4	interacts_with	gene	0.55
ALZHEIMER	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TREM1 in their description or question text

No additional research found