disease

Dysbiosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Dysbiosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

348Connections

4Hypotheses

0Analyses

35Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Disease Info

Associated Genes	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, ANXIETY, AUTOPHAGY, C3AR1, CANCER, CRHR1
KG Connections	341 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Gut Microbiota Dysbiosis

phenotype · 707 words

→

Pathway Diagram

graph TD
    Dysbiosis["Dysbiosis"]
    Parkinson_s_Disease{"Parkinson's Disease"}
    Dysbiosis -->|"risk_factor_for"| Parkinson_s_Disease
    Neuroinflammation["Neuroinflammation"]
    Dysbiosis -->|"causes"| Neuroinflammation
    Blood_Brain_Barrier_Permeabili["Blood-Brain Barrier Permeability"]
    Dysbiosis -->|"causes"| Blood_Brain_Barrier_Permeabili
    Inflammation{"Inflammation"}
    Inflammation -->|"associated_with"| Dysbiosis
    Als{"Als"}
    Als -->|"therapeutic_target"| Dysbiosis
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"associated_with"| Dysbiosis
    style Dysbiosis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (35)

Target	Relation	Type	Str
depression	associated_with	disease	0.95
Oxidative Stress	contributes_to	process	0.90
Oxidative Stress	promotes	process	0.90
Neuroinflammation	promotes	process	0.90
Neuroinflammation	causes	process	0.90
Parkinson's Disease	associated_with	disease	0.90
NEUROINFLAMMATION	contributes_to	process	0.88
Retinal Ganglion Cell Degeneration	mediates	process	0.85
LPS-TLR4 pathway	activates	pathway	0.85
Blood-Brain Barrier Integrity	associated_with	phenotype	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Blood-Brain Barrier Permeability	causes	phenotype	0.85
Parkinson'S Disease	causes	disease	0.85
glaucoma	promotes	disease	0.80
retinal ganglion cell degeneration	promotes	process	0.80
inflammaging	promotes	process	0.80
NLRP3	activates	gene	0.70
SYNUCLEIN	associated_with	concept	0.50
Gut Microbiota	activates	process	0.50
α-SYNUCLEIN	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Gut Microbiome	activates	process	0.50
Telomere	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
Telomere	inhibits	pathway	0.50
Proteostasis	regulates	process	0.50
Cellular Senescence	regulates	cell_type	0.50
CHRONIC INFLAMMATION	regulates	concept	0.50
Telomere	regulates	pathway	0.50
Gut Microbiota	interacts_with	process	0.50
Gut Microbiota	causes	process	0.50
MAPK SIGNALING	activates	concept	0.50
Gut Microbiota	inhibits	process	0.50
Gut Microbiota	regulates	process	0.50
Gut Microbiota	associated_with	process	0.50

Incoming (313)

Source	Relation	Type	Str
Inflammation	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
Inflammation	activates	disease	0.90
INFLAMMATION	activates	gene	0.90
AGING	associated_with	gene	0.90
Als	activates	disease	0.90
Aging	associated_with	disease	0.90
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.90
INFLAMMATION	associated_with	gene	0.90
Parkinson	therapeutic_target	disease	0.90
PARKINSON	therapeutic_target	gene	0.90
PARKINSON'S DISEASE	therapeutic_target	gene	0.90
Inflammation	treats	disease	0.80
OXIDATIVE STRESS	associated_with	gene	0.80
ALZHEIMER	regulates	gene	0.80
Alzheimer	regulates	disease	0.80
INFLAMMATION	treats	gene	0.80
IL-6	therapeutic_target	gene	0.80
NEURODEGENERATIVE DISEASES	associated_with	gene	0.80
Inflammation	therapeutic_target	disease	0.80
INFLAMMATION	causes	gene	0.80
Inflammation	regulates	disease	0.80
Senescence	associated_with	disease	0.80
Inflammation	causes	disease	0.80
obesity	promotes	phenotype	0.75
FERROPTOSIS	associated_with	gene	0.70
Neuroinflammation	treats	disease	0.70
NEUROINFLAMMATION	treats	gene	0.70
NEUROINFLAMMATION	associated_with	gene	0.70
Neuroinflammation	associated_with	disease	0.70
Inflammation	interacts_with	disease	0.70
Neuroinflammation	interacts_with	disease	0.70
Als	regulates	disease	0.70
NEUROINFLAMMATION	interacts_with	gene	0.70
MITOCHONDRIA	associated_with	gene	0.70
depression	associated_with	phenotype	0.70
Depression	therapeutic_target	disease	0.70
DEPRESSION	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	regulates	gene	0.70
Depression	activates	disease	0.70
PARKINSON	associated_with	gene	0.70
CYTOKINES	activates	gene	0.70
GUT-BRAIN AXIS	treats	gene	0.70
TNF	activates	gene	0.70
BDNF	activates	gene	0.70
IL-6	activates	gene	0.70
TNF-Α	activates	gene	0.70
STROKE	activates	gene	0.70
DEPRESSION	activates	gene	0.70

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut dysbiosis-driven monocyte reprogramming toward NETotic p	0.380	Alzheimer's disease	Systemic immune profiling and peripheral
plasma LPS-binding protein separates causal from compensator	0.346	neurodegeneration	How does gut microbiome dysbiosis contri
TLR4 priming is the actionable driver in: How does gut micro	0.343	neurodegeneration	How does gut microbiome dysbiosis contri
microglial inflammasome tone defines the therapeutic window	0.341	neurodegeneration	How does gut microbiome dysbiosis contri

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Iron and the Intestinal Microbiome. [PMID:40603801]	Li H	Adv Exp Med Biol	2025
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP- [PMID:40958035]	Li Z, Sun X, Wang Y	Basic Res Cardiol	2025
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024
Joint-specific memory, resident memory T cells and the rolling window of opportu [PMID:38600215]	Chang MH, Fuhlbrigge RC, Nigrovic PA	Nat Rev Rheumatol	2024
Oral Microbiome: A Review of Its Impact on Oral and Systemic Health. [PMID:39338471]	Rajasekaran JJ, Krishnamurthy HK, Bosco	Microorganisms	2024
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662]	["Zhang Di", "Jing Bei", "Chen Zhen-Ni",	CNS neuroscience & therapeutic	2023
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081]	Park, Hwang, Lee, Jang, Jeong et al.	Frontiers in immunology	2023
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081]	Unknown	Frontiers in immunology	2023
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662]	["Zhang Di", "Jing Bei", "Chen Zhen-Ni",	CNS neuroscience & therapeutic	2023
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023
The role of Toll-like receptors and neuroinflammation in Parkinson's disease. [PMID:35668422]	["Heidari Arash", "Yazdanpanah Niloufar"	Journal of neuroinflammation	2022
Pyroptosis in acute pancreatitis and its therapeutic regulation. [PMID:35687256]	Al Mamun A, Suchi SA, Aziz MA	Apoptosis	2022
Microglia in multiple sclerosis: Protectors turn destroyers. [PMID:35882229]	Yong	Neuron	2022
Microglia in multiple sclerosis: Protectors turn destroyers. [PMID:35882229]	Unknown	Neuron	2022
The role of Toll-like receptors and neuroinflammation in Parkinson's disease. [PMID:35668422]	["Heidari Arash", "Yazdanpanah Niloufar"	Journal of neuroinflammation	2022
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory sign [PMID:33057840]	["Ciesielska A", "Matyjek M", "Kwiatkows	Cellular and molecular life sc	2021
Neuroinflammation in neurodegenerative disorders: the roles of microglia and ast [PMID:33239064]	Kwon, Koh	Translational neurodegeneratio	2021
AIM2 in regulatory T cells restrains autoimmune diseases. [PMID:33505023]	Chou WC, Guo Z, Guo H	Nature	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Dysbiosis in their description or question text

No additional research found