gene

STROKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STROKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5477Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

STROKE is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 1440 entities in the SciDEX knowledge graph.

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Regenerate portrait ↻

🧬 Gene Info

Gene Symbol	STROKE
Aliases	Cerebrovascular accident, CVA, Brain attack
Size	Particles typically 10-200 nm to exploit enhanced permeability and retention (EPR) effect
Surface properties	PEGylation to reduce opsonization and extend circulation time
Targeting ligands	Antibodies or peptides targeting brain-specific receptors (transferrin receptor, LDL receptor)
Drug loading	Controlled release mechanisms (pH-triggered, enzyme-triggered, or ultrasound-triggered)
Hemorrhage	Excessive pressure can cause microhemorrhages
Thermal damage	Prolonged exposure can heat tissue
Permanent BBB disruption	Parameters must be optimized to ensure reversibility
Associated Diseases	aging, Als, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	APIGENIN, CURCUMIN, MELATONIN, NICOTINAMIDE, NMN, QUERCETIN
Interactions	ACAT1, ACC, ACSL4, Actin, AEP, AGING
KG Connections	3224 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Focused Ultrasound-Enhanced Nanoparticle Delivery

idea · 2215 words

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Pathway Diagram

graph TD
    STROKE["STROKE"] -->|"associated"| TREM2["TREM2"]
    STROKE["STROKE"] -->|"associated"| Heart_Failure["Heart Failure"]
    STROKE["STROKE"] -->|"associated"| Diabetes["Diabetes"]
    STROKE["STROKE"] -->|"associated"| Cancer["Cancer"]
    STROKE["STROKE"] -->|"associated"| Neurodegeneration["Neurodegeneration"]
    STROKE["STROKE"] -->|"associated"| Stroke["Stroke"]
    APP["APP"] -->|"associated"| STROKE["STROKE"]
    GDNF["GDNF"] -->|"associated"| STROKE["STROKE"]
    GFAP["GFAP"] -->|"associated"| STROKE["STROKE"]
    IGF1["IGF1"] -->|"associated"| STROKE["STROKE"]
    style STROKE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2423)

Target	Relation	Type	Str
Oxidative Stress	therapeutic_target	pathway	1.00
Als	regulates	disease	1.00
Als	activates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Als	inhibits	disease	1.00
AKT	activates	gene	1.00
Neuroinflammation	regulates	disease	1.00
MICROGLIA	activates	gene	1.00
Ischemia	inhibits	disease	1.00
Cardiovascular	inhibits	disease	1.00
Ischemia	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Oxidative Stress	regulates	pathway	1.00
Neuroinflammation	activates	disease	1.00
Neurodegeneration	regulates	disease	1.00
NEUROINFLAMMATION	regulates	gene	1.00
Apoptosis	regulates	pathway	1.00
Alzheimer	activates	disease	1.00
Stroke	causes	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Apoptosis	activates	pathway	1.00
Hypertension	associated_with	disease	1.00
AGING	associated_with	gene	1.00
Als	associated_with	disease	1.00
MICROGLIA	regulates	gene	1.00
Stroke	inhibits	disease	1.00
Blood-Brain Barrier	therapeutic_target	pathway	1.00
Aging	associated_with	disease	1.00
Heart Failure	associated_with	disease	1.00
Inflammation	regulates	disease	1.00
Stroke	regulates	disease	1.00
Apoptosis	inhibits	pathway	1.00
Immune Response	activates	pathway	1.00
Neurodegeneration	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Stroke	activates	disease	1.00
Aging	activates	disease	1.00
Oxidative Stress	regulates	pathway	1.00
Apoptosis	regulates	pathway	1.00
Diabetes	associated_with	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Stroke	expressed_in	disease	1.00
Neuroinflammation	associated_with	disease	1.00
Autophagy	therapeutic_target	pathway	1.00
Inflammation	associated_with	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Neuroinflammation	inhibits	disease	1.00

Incoming (3054)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
AKT	associated_with	gene	1.00
BRAIN INJURY	associated_with	gene	1.00
ASTROCYTES	activates	gene	1.00
Als	associated_with	disease	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
INFLAMMATION	inhibits	gene	1.00
NEURODEGENERATION	activates	gene	1.00
BRAIN INJURY	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
INFLAMMATION	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
BRAIN INJURY	therapeutic_target	gene	1.00
Cardiovascular	associated_with	disease	1.00
GENES	associated_with	gene	1.00
Als	activates	disease	1.00
AGING	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
Aging	activates	disease	1.00
Parkinson	associated_with	disease	1.00
STROKE	expressed_in	gene	1.00
STROKE	biomarker_for	gene	1.00
AKT	activates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
NEURODEGENERATION	activates	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
STROKE	protects_against	gene	1.00
STROKE	therapeutic_target	gene	1.00
MITOPHAGY	activates	gene	1.00
TNF	activates	gene	1.00
CYTOKINES	inhibits	gene	1.00
NRF2	activates	gene	1.00
FERROPTOSIS	associated_with	gene	1.00
Neuroinflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
TNF	inhibits	gene	1.00
TNF-Α	inhibits	gene	1.00
PARKINSON	associated_with	gene	1.00
NRF2	associated_with	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
APOPTOSIS	inhibits	gene	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the molecular determinants that control directional mitochondrial trans

cellular neuroscience | 2026-04-12 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate proposed bioenergetic gradients drive transfer but didn't identify th

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning STROKE in their description or question text

No additional research found