gene

LAMTOR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMTOR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

1Hypotheses

1Analyses

28Outgoing

11Incoming

0Experiments

1Debates

Summary

Page for LAMTOR1 - Late Endosomal/Lysosomal Adaptor 1

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🧬 Gene Info

Gene Symbol	LAMTOR1
Full Name	Late Endosomal/Lysosomal Adaptor 1
Aliases	Page for LAMTOR1
Function	LAMTOR1 (Late Endosomal/Lysosomal Adaptor 1) is a key component of the ragulator complex that regulates mTORC1 signaling.
Pathways	MTOR, mTOR, MAPK, mtor
Ensembl ID	ENSG00000149357
GeneCards	LAMTOR1
Human Protein Atlas	LAMTOR1
mTORC1 Activation	LAMTOR1 is essential for mTORC1 activation by amino acids. The ragulator complex localizes to lysosomes where it activates mTORC1 in response to nutrient availability.
Rag GTPase Regulation	LAMTOR1 forms a complex with LAMTOR2 and LAMTOR3, acting as a guanine nucleotide exchange factor (GEF) for Rag GTPases.
Lysosomal Trafficking	The LAMTOR complex regulates endosomal and lysosomal trafficking, influencing autophagy and nutrient sensing.
ERK Pathway Modulation	LAMTOR1 also modulates ERK/MAPKmechanisms/mapk-signaling-neurodegeneration) signaling, connecting it to cell growth and differentiation.
Autophagy Impairment	LAMTOR1 is crucial for autophagy, and its dysfunction may lead to accumulation of amyloid and tau aggregates.
Lysosomal Function	The protein's role in lysosomal signaling affects cellular waste clearance, which is impaired in AD.
Autophagy-Lysosome Pathway	LAMTOR1 dysfunction contributes to impaired autophagy and α-synuclein clearance.
Associated Diseases	neurodegeneration
Interactions	AND, AUTOPHAGY, MAPK, MTOR, MTORC1
SciDEX Hypotheses	Mitochondrial-Lysosomal Coupling Enhancer
KG Connections	39 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LAMTOR1 - Late Endosomal/Lysosomal Adaptor 1

gene · 597 words

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Pathway Diagram

graph TD
    LAMTOR1["LAMTOR1"]
    Fibrosis{"Fibrosis"}
    LAMTOR1 -->|"therapeutic target"| Fibrosis
    Hepatitis{"Hepatitis"}
    LAMTOR1 -->|"therapeutic target"| Hepatitis
    Cancer{"Cancer"}
    LAMTOR1 -->|"therapeutic target"| Cancer
    Cirrhosis{"Cirrhosis"}
    LAMTOR1 -->|"therapeutic target"| Cirrhosis
    Inflammation{"Inflammation"}
    LAMTOR1 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    LAMTOR1 -->|"therapeutic target"| Ms
    AMPK["AMPK"]
    LAMTOR1 -->|"therapeutic target"| AMPK
    MTOR["MTOR"]
    LAMTOR1 -->|"therapeutic target"| MTOR
    Mtor(["Mtor"])
    LAMTOR1 -->|"therapeutic target"| Mtor
    Autophagy(["Autophagy"])
    LAMTOR1 -->|"activates"| Autophagy
    Mapk(["Mapk"])
    LAMTOR1 -->|"activates"| Mapk
    INFLAMMATION["INFLAMMATION"]
    LAMTOR1 -->|"therapeutic target"| INFLAMMATION
    MTOR -->|"therapeutic target"| LAMTOR1
    style LAMTOR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Mtor	activates	pathway	0.60
Ampk Signaling	therapeutic_target	pathway	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
MTORC1	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
MTOR	therapeutic_target	gene	0.60
Mtor	therapeutic_target	pathway	0.60
Mapk	activates	pathway	0.60
Autophagy	activates	pathway	0.60
AMPK	therapeutic_target	gene	0.60
neurodegeneration	associated_with	disease	0.50
mTOR	regulates	pathway	0.50
TFE3	co_associated_with	gene	0.40
TFEB	co_associated_with	gene	0.40
ULK1	co_associated_with	gene	0.40
YWHAG	co_associated_with	gene	0.40

Incoming (11)

Source	Relation	Type	Str
h-e3a48208	targets	hypothesis	0.90
MTOR	activates	gene	0.60
AND	activates	gene	0.60
MTORC1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MAPK	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
ATP6V1A	co_associated_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial-Lysosomal Coupling Enhancer	0.585	neurodegeneration	Does TFEB dysfunction cause neurodegener

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.697

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
ZDHHC9 palmitoylates LAMTOR1 to promote renal cell carcinoma malignant progressi [PMID:41856969]	Liu B, Hou T, Liu X, Liu L, Ma Z et al.	Cell Death Dis	2026	0

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted TFEB's role in mitochondrial-lysosomal coupling but could

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning LAMTOR1 in their description or question text

No additional research found