gene 1,196 words KG: WIPI4
Contents

WIPI4 Gene

🧬 Gene Info
Gene SymbolWIPI4
Chromosome19p13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight44 kDa
Amino Acids371 aa
PathwaysAutophagy
UniProt IDQ9N5Z0
NCBI Gene ID162317
Ensembl IDENSG00000168096
OMIM614402
GeneCardsWIPI4
Human Protein AtlasWIPI4
Associated DiseasesAls, Ms, Neurodegeneration
InteractionsATG, ATG16L1, atg2a, ATG2A, AUTOPHAGY, ERK
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

APOE-Dependent Autophagy Restoration
Score: 0.88
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

blarcamesine-axon
clinical_trial · KG edge: regulates
Neurodegeneration
disease · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: regulates
Mitochondria
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: causes

Knowledge Graph (12 edges)

WDR45 encodes WIPI4
WIPI4 regulates autophagy
WIPI4 regulates ferroptosis
ATG16L1 activates WIPI4
MYC activates WIPI4
GABARAP activates WIPI4
WIPI3 regulates WIPI4
WIPI2 activates WIPI4
WIPI4 activates WIPI1
WIPI4 activates LC3

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