gene

atg2a

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atg2a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

33Outgoing

15Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ATG2A
Full Name	Autophagy Related 2A
Chromosome	11q13.2
Protein Type	Peripheral Membrane Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	the autophagosomal membrane
Molecular Weight	206 kDa
UniProt ID	[Q9BSB5](https://www.uniprot.org/uniprot/Q9BSB5)
GeneCards	ATG2A
Human Protein Atlas	ATG2A
Membrane tethering	ATG2A bridges the growing autophagosome (phagophore) with ER-derived membranes
Lipid transfer	ATG2A functions as a lipid transfer protein (LTP), mediating phospholipid delivery from ER to autophagosomal membranes
WIPI proteins	ATG2A interacts with WIPI1/2/3/4 (WD repeat domain phosphoinositide-interacting proteins) to localize to the autophagosomal membrane
Associated Diseases	Neurodegeneration, neurodegeneration
Interactions	WIPI4
KG Connections	3 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATG2A

gene · 693 words

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Pathway Diagram

graph TD
    ATG2A["ATG2A"]
    ATG2A -->|"participates in"| autophagosome_lysosome_fusion["autophagosome-lysosome fusion"]
    ATG2A -->|"regulates"| phosphatidylethanolamine["phosphatidylethanolamine"]
    ATG2A -->|"activates"| Ms["Ms"]
    ATG2A -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ATG2A -->|"activates"| Ferroptosis["Ferroptosis"]
    ATG2A -->|"activates"| Autophagy["Autophagy"]
    ATG2A -->|"activates"| WIPI4["WIPI4"]
    E2F4["E2F4"] -->|"regulates"| ATG2A
    WIPI4 -->|"interacts"| ATG2A
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| ATG2A
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| ATG2A
    WDR45["WDR45"] -->|"activates"| ATG2A
    MITOCHONDRIA["MITOCHONDRIA"] -->|"activates"| ATG2A
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ATG2A

Outgoing (33)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG2A	data_in	dataset_row	0.00
Autophagy	involved_in	process	0.95
autophagosome-lysosome fusion	participates_in	biological_process	0.90
Brain Atrophy	causes	phenotype	0.90
Phosphatidylserine	mediates	compound	0.90
LC3B	interacts_with	protein	0.88
Developmental Regression	associated_with	phenotype	0.85
phosphatidylethanolamine	regulates	protein	0.70
Neurodegeneration	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Ms	activates	disease	0.65
Autophagy	activates	pathway	0.60
Ferroptosis	causes	pathway	0.60
Autophagy	causes	pathway	0.60
AUTOPHAGY	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
Raf	causes	protein	0.60
autophagy pathway	participates_in	pathway	0.60
LC3B	expressed_in	gene	0.60
neurodegenerative_disorders	causes	disease	0.60
developmental_regression	causes	disease	0.60
WIPI4	activates	gene	0.60
WDR45	causes	gene	0.60
Ferroptosis	activates	pathway	0.60
epilepsy	associated_with	disease	0.60
neurodegeneration	causes	disease	0.60
neurodegeneration	associated_with	disease	0.60
MITOCHONDRIA	activates	gene	0.60
AND	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
MITOCHONDRIA	activates	cell_type	0.50
WIPI4	activates	gene	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50

Incoming (15)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATG2A	data_in	dataset_row	0.00
E2F4	regulates	protein	0.90
WIPI4	regulates	protein	0.88
WIPI4	interacts_with	protein	0.80
YTHDF1	associated_with	protein	0.80
NEURODEGENERATION	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AUTOPHAGY	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
WDR45	activates	gene	0.60
WDR45	causes	gene	0.60
WIPI4	activates	gene	0.60
FERROPTOSIS	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning atg2a in their description or question text

No additional research found