gene

WIPI3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

6Outgoing

7Incoming

0Experiments

0Debates

Summary

WIPI3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WIPI3
Chromosome	19p13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	47 kDa
Amino Acids	328 aa
Pathways	Autophagy
UniProt ID	Q9Y5P8
NCBI Gene ID	55068
Ensembl ID	ENSG00000196865
OMIM	614151
GeneCards	WIPI3
Human Protein Atlas	WIPI3
Associated Diseases	neurodegeneration
Interactions	ATG, ATG16L1, ERK, GABARAP, LC3, MYC
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WIPI3 — AlphaFold Q9Y5P8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WIPI3 Gene

gene · 1110 words

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WIPI3 Protein

protein · 618 words

→

Pathway Diagram

graph TD
    WIPI3["WIPI3"]
    WIPI2["WIPI2"]
    WIPI3 -->|"activates"| WIPI2
    AMPK["AMPK"]
    WIPI3 -->|"regulates"| AMPK
    WIPI4["WIPI4"]
    WIPI3 -->|"regulates"| WIPI4
    WIPI1["WIPI1"]
    WIPI3 -->|"activates"| WIPI1
    LC3["LC3"]
    WIPI3 -->|"activates"| LC3
    Autophagy(["Autophagy"])
    WIPI3 -->|"regulates"| Autophagy
    neurodegeneration["neurodegeneration"]
    WIPI3 -->|"implicated in"| neurodegeneration
    ERK["ERK"]
    ERK -->|"activates"| WIPI3
    ATG16L1["ATG16L1"]
    ATG16L1 -->|"activates"| WIPI3
    ATG["ATG"]
    ATG -->|"activates"| WIPI3
    MYC["MYC"]
    MYC -->|"activates"| WIPI3
    GABARAP["GABARAP"]
    GABARAP -->|"activates"| WIPI3
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| WIPI3
    style WIPI3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
WIPI2	activates	gene	0.60
WIPI4	regulates	gene	0.60
WIPI1	activates	gene	0.60
LC3	activates	gene	0.60
AMPK	regulates	gene	0.60
Autophagy	regulates	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
genes-wipi3	linked_to	wiki_page	1.00
ERK	activates	gene	0.60
ATG	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ATG16L1	activates	gene	0.60
MYC	activates	gene	0.60
GABARAP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WIPI3 in their description or question text

No additional research found