gene

UHRF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UHRF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

11Outgoing

27Incoming

0Experiments

0Debates

Summary

UHRF1 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, implicated in. Associated with Als, Cancer, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UHRF1
Full Name	Ubiquitin-like with PHD and RING Finger Domains 1
Chromosome	19p13.3
Function	UHRF1 is a key epigenetic regulator that bridges DNA methylation and histone modifications.
Primary Expression	cancers and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease
Molecular Weight	110 kDa
Amino Acids	782 aa
Pathways	Nf-Κb
UniProt ID	Q96T23
Ensembl ID	ENSG00000048828
OMIM	607909
GeneCards	UHRF1
Human Protein Atlas	UHRF1
DNA Methylation Maintenance	Recruits DNMT1 to replication forks
Histone Binding	Reads histone modifications (H3K9me3)
Associated Diseases	neurodegeneration
Interactions	AMPK, ARG1, CYTOKINES, IL-1, IL-10, IL-4
KG Connections	38 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: UHRF1 — AlphaFold Q96T23 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UHRF1 Gene

gene · 501 words

→

UHRF1 Protein

protein · 642 words

→

Pathway Diagram

graph TD
    UHRF1["UHRF1"]
    Als{"Als"}
    UHRF1 -->|"biomarker for"| Als
    Ms{"Ms"}
    UHRF1 -->|"biomarker for"| Ms
    Cancer{"Cancer"}
    UHRF1 -->|"biomarker for"| Cancer
    Tumor{"Tumor"}
    UHRF1 -->|"biomarker for"| Tumor
    neurodegeneration["neurodegeneration"]
    UHRF1 -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"biomarker for"| UHRF1
    MMP7["MMP7"]
    MMP7 -->|"associated with"| UHRF1
    MMP1["MMP1"]
    MMP1 -->|"associated with"| UHRF1
    CDC25B["CDC25B"]
    CDC25B -->|"associated with"| UHRF1
    CD8["CD8"]
    CD8 -->|"biomarker for"| UHRF1
    CANCER["CANCER"]
    CANCER -->|"biomarker for"| UHRF1
    GBM["GBM"]
    GBM -->|"biomarker for"| UHRF1
    CDK4["CDK4"]
    CDK4 -->|"associated with"| UHRF1
    style UHRF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

Target	Relation	Type	Str
Neuroinflammation	activates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
MAPK signaling	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
CYTOKINES	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
Microglia	activates	cell_type	0.60
IL-10	activates	gene	0.60

Incoming (27)

Source	Relation	Type	Str
AMPK	activates	gene	0.60
IL-1	activates	gene	0.60
IL-4	activates	gene	0.60
IL-6	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TNC	activates	gene	0.60
ARG1	activates	gene	0.60
ABCA7	expressed_in	gene	0.60
ARF1	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
E2F2	expressed_in	gene	0.60
ELAVL1	expressed_in	gene	0.60
GRID2	expressed_in	gene	0.60
MAPK7	expressed_in	gene	0.60
RIPK2	expressed_in	gene	0.60
CANCER	biomarker_for	gene	0.60
G6PD	expressed_in	gene	0.60
MAP	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60
MRPS31	expressed_in	gene	0.60
CD4	biomarker_for	gene	0.60
MMP7	associated_with	gene	0.60
MMP1	associated_with	gene	0.60
CDC25B	associated_with	gene	0.60
CD8	biomarker_for	gene	0.60
GBM	biomarker_for	gene	0.60
CDK4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UHRF1 in their description or question text

No additional research found