Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAP1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MAP1A |
| Chromosome | 15q15.2. |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 250 kDa |
| Amino Acids | 248 aa |
| Pathways | NF-kB signaling |
| Ensembl ID | ENSG00000118789 |
| GeneCards | MAP1A |
| Human Protein Atlas | MAP1A |
| [Cortex](/brain-regions/cortex) | Strong expression in layer II-III pyramidal neurons |
| Cerebellum | Abundant in Purkinje cells and granule cells |
| Basal ganglia | Moderate expression in striatal medium spiny neurons |
| Brainstem | Present in various nuclei including the locus coeruleus |
| Microtubule Stabilization | Promotes microtubule assembly and prevents depolymerization, essential for maintaining axonal integrity |
| Axonal Transport Facilitation | Functions as a molecular scaffold for motor protein complexes, enabling efficient transport of vesicles, organelles, and signaling molecules along microtubules |
| Associated Diseases | neurodegeneration |
| Interactions | MAP1B, MAP2, MAP6 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MAP1A["MAP1A"]
style MAP1A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
MAP1B["MAP1B"]
MAP2["MAP2"]
MAP6["MAP6"]
neuroinflammation["neuroinflammation"]
NF_kB_signaling(("NF-kB signaling"))
neurodegeneration["neurodegeneration"]
MAP1A -->|"activates"| MAP1B
MAP1A -->|"activates"| MAP2
MAP1A -->|"activates"| MAP6
MAP1A -->|"activates"| neuroinflammation
MAP1A -->|"participates_in"| NF_kB_signaling
MAP1A -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class MAP1B gene
class MAP2 gene
class MAP6 gene
class neuroinflammation protein
class NF_kB_signaling pathway
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| Ovarian Cancer | biomarker_for | disease | 0.75 |
| XPR1 | associated_with | gene | 0.60 |
| NFE2L3 | associated_with | gene | 0.60 |
| SIGLEC11 | associated_with | gene | 0.60 |
| SLC24A4 | associated_with | gene | 0.60 |
| SPINT1 | associated_with | gene | 0.60 |
| MYL9 | associated_with | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.55 |
| MAP1B | activates | gene | 0.55 |
| MAP2 | activates | gene | 0.55 |
| MAP6 | activates | gene | 0.55 |
| neuroinflammation | activates | disease | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MAP1A in their description or question text
No additional research found