gene 1,063 words KG: PRMT5
Contents

PRMT5

🧬 Gene Info
Gene SymbolPRMT5
Full NameProtein Arginine Methyltransferase 5
Chromosome14q11.2
Protein TypeTransferase
Functionencodes a type II protein arginine methyltransferase that catalyzes symmetric dimethylation of arginine residues on histones and non-histone substrates.
PathwaysStem Cell
UniProt IDO14744
Ensembl IDENSG00000100462
OMIM604045
GeneCardsPRMT5
Human Protein AtlasPRMT5
Associated DiseasesAD, Als, ARM, brain disorders, BREAST CANCER
Known Drugs/CompoundsPARP inhibitor
InteractionsAND, APOPTOSIS, AUTOPHAGY, CANCER, CDK4, DNA
KG Connections163 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
PARP1 Inhibition Therapy
Score: 0.74
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Arginine Methylation Enhancement Therapy
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Exosomes
entity · KG edge: expressed_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: inhibits

Knowledge Graph (12 edges)

PRMT1 inhibits PRMT5
PRMT5 implicated_in brain disorders
GPX4 inhibits PRMT5
PRMT5 inhibits PRMT1
PRMT5 regulates PRMT1
PRMT1 regulates PRMT5
TLR3 therapeutic_target PRMT5
PRMT5 therapeutic_target JAK1
PRMT5 therapeutic_target MYC
PRMT5 activates STAT3

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