| Gene Symbol | P75NTR |
| Chromosome | 17q21.33 |
| Protein Family | TNF receptor superfamily (TNFRSF16) |
| Protein Type | Receptor |
| Function | is a member of the tumor necrosis factor receptor superfamily that serves as a key modulator of neurotrophin signaling. |
| Subcellular Localization | </th><td>Cell membrane, endosomes, nucleus</td></tr> [@matsuda2010] |
| Molecular Weight | 75 kDa |
| Amino Acids | 427 aa |
| Exons | 6 |
| Pathways | NF-κB |
| GeneCards | P75NTR |
| Human Protein Atlas | P75NTR |
| Full-length p75NTR | The canonical receptor with intact intracellular domain |
| p75NTR-Δ | Truncated isoform lacking the death domain, acts as a dominant-negative |
| p75NTR-S | Short isoform with alternative C-terminus |
| Associated Diseases | Als, Alzheimer, Cancer, Depression, Glioblastoma |
| Interactions | AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS |
| KG Connections | 146 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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