Contents

NPM1 Gene

🧬 Gene Info

Gene Symbol	NPM1
Aliases	Nucleophosmin
Chromosome	5q35.1
Protein Type	Chaperone
Target Class	Chaperone
Function	Small molecule modulators of nucleolar function and protein interactions
Mechanism of Action	Small molecule modulators of nucleolar function and protein interactions
Subcellular Localization	, shuttling between the nucleolus, nucleoplasm, and cytoplasm in response to cellular stress conditions. This traffickin
Druggability	Low (0.30)
Clinical Stage	Phase III
Molecular Weight	37 kDa
Amino Acids	294 aa
Exons	12
Pathways	Apoptosis
UniProt ID	A0A7I2V5J8
Ensembl ID	ENSG00000126016
GeneCards	NPM1
Human Protein Atlas	NPM1
Associated Diseases	Acute Myeloid Leukemia, Als, cancer
Known Drugs/Compounds	NSC348884
Interactions	AMYOTROPHIC LATERAL SCLEROSIS, AND, ARHGEF2, ARID1A, C9ORF72, CANCER
SciDEX Target	View Target Profile (10 clinical trials)
SciDEX Hypotheses	Nucleolar Stress Response Normalization
KG Connections	300 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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