concept

NAD+ METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAD+ METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

4Analyses

5Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	NAD+ METABOLISM

Pathway Diagram

graph TD
    NAD__METABOLISM[NAD+ METABOLISM]
    NAD__METABOLISM -->|drives| cancer[cancer]
    NAD__METABOLISM -->|regulates| immune_system[immune system]
    NAD__METABOLISM -->|regulates| aging[aging]
    NAD__METABOLISM -->|regulates| Stemness[Stemness]
    SIRT1[SIRT1] -->|participates in| NAD__METABOLISM
    nicotinamide[nicotinamide] -->|modulates| NAD__METABOLISM
    neurodegeneration[neurodegeneration] -->|involves| NAD__METABOLISM
    NAD[NAD] -->|participates in| NAD__METABOLISM
    neurons[neurons] -->|active_in| NAD__METABOLISM
    NADH[NADH] -->|participates in| NAD__METABOLISM
    DAM_microglia[DAM microglia] -->|active_in| NAD__METABOLISM
    AMPK[AMPK] -->|participates in| NAD__METABOLISM
    ATP[ATP] -->|participates in| NAD__METABOLISM
    CD38[CD38] -->|regulates| NAD__METABOLISM

Outgoing (5)

Target	Relation	Type	Str
aging	regulates	process	0.85
cancer	drives	disease	0.85
immune system	regulates	pathway	0.85
Aging-Associated Diseases	associated_with	disease	0.80
Stemness	regulates	phenotype	0.75

Incoming (67)

Source	Relation	Type	Str
SIRT1	regulates	gene	0.90
SIRT1	regulates	gene	0.90
SIRT1	links	enzyme	0.90
nicotinamide	modulates	drug	0.85
SIRT1	participates_in	gene	0.85
neurodegeneration	involves	disease	0.85
NAD	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
NADH	participates_in	gene	0.85
DAM microglia	active_in	cell_type	0.85
AMPK	participates_in	gene	0.85
ATP	participates_in	gene	0.85
CD38	regulates	gene	0.80
PS1	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
Alzheimer's disease	involves	disease	0.75
NAMPT	participates_in	gene	0.75
resveratrol	modulates	drug	0.75
APP	participates_in	gene	0.75
PARP1	participates_in	gene	0.75
SIRT3	participates_in	gene	0.75
NRF1	participates_in	gene	0.75
TFAM	participates_in	gene	0.75
FOXO3	participates_in	gene	0.75
DNA	participates_in	gene	0.75
metformin	modulates	drug	0.65
CLOCK	participates_in	gene	0.65
BMAL1	participates_in	gene	0.65
neuroinflammation	involves	disease	0.65
SIRT6	participates_in	gene	0.65
microglia	active_in	cell_type	0.65
Parkinson's disease	involves	disease	0.65
FOXO	participates_in	gene	0.65
HIF	participates_in	gene	0.55
IL-6	participates_in	gene	0.55
T cells	active_in	cell_type	0.55
RNA	participates_in	gene	0.55
rapamycin	modulates	drug	0.55
ALS	involves	disease	0.55
ACC	participates_in	gene	0.55
Huntington's disease	involves	disease	0.55
HDAC	participates_in	gene	0.55
CD38	participates_in	gene	0.55
COX5A	participates_in	gene	0.55
RORB	participates_in	gene	0.55
STX17	participates_in	gene	0.55
inhibitory neurons	active_in	cell_type	0.55
PINK1	participates_in	gene	0.55
excitatory neurons	active_in	cell_type	0.55
TFEB	participates_in	gene	0.55