concept

LIPID PEROXIDATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPID PEROXIDATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

8Experiments

4Debates

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💡 Concept Info

Name	LIPID PEROXIDATION
Key Genes/Proteins	ACSL4, APOE, APOE4, ATG5, BECN1
Related Diseases	ALZHEIMER'S DISEASE, APOPTOSIS, ATP, CELL DEATH, DOPAMINE
Related Pathways	CALCIUM SIGNALING

Pathway Diagram

graph TD
    LIPID_PEROXIDATION["LIPID PEROXIDATION"]
    LIPID_PEROXIDATION -->|"involved_in"| Ferroptosis["Ferroptosis"]
    LIPID_PEROXIDATION -->|"causes"| Cellular_Membrane_Destruction["Cellular Membrane Destruction"]
    LIPID_PEROXIDATION -->|"causes"| Ferroptotic_Cell_Death["Ferroptotic Cell Death"]
    LIPID_PEROXIDATION -->|"causes"| Lysosomal_Damage["Lysosomal Damage"]
    LIPID_PEROXIDATION -->|"causes"| Lipofuscinosis["Lipofuscinosis"]
    NADPH["NADPH"] -->|"inhibits"| LIPID_PEROXIDATION
    Ferroptosis -->|"mediates"| LIPID_PEROXIDATION
    ZnONPs["ZnONPs"] -->|"causes"| LIPID_PEROXIDATION
    GPX4["GPX4"] -->|"inhibits"| LIPID_PEROXIDATION
    Ferrostatin_1["Ferrostatin-1"] -->|"inhibits"| LIPID_PEROXIDATION
    AMPK["AMPK"] -->|"inhibits"| LIPID_PEROXIDATION

Outgoing (60)

Target	Relation	Type	Str
Cellular Membrane Destruction	causes	phenotype	0.95
Ferroptosis	associated_with	process	0.95
Ferroptosis	biomarker_for	process	0.90
Lysosomal Damage	causes	process	0.90
Lipofuscinosis	causes	phenotype	0.90
Ferroptosis	mediates	process	0.90
Ferroptotic Cell Death	causes	process	0.90
ferroptosis	drives	process	0.90
metabolic dysfunction-associated fatty liver disease	drives	disease	0.88
Thromboinflammation	contributes_to	process	0.85
IFNB	upregulates	gene	0.85
ferroptosis	upstream_of	process	0.80
STING	inhibits	protein	0.80
NEUROINFLAMMATION	inhibits	phenotype	0.70
Mitochondrial damage	causes	mechanism	0.70
Protein aggregation	enhances	mechanism	0.70
Microglial activation	activates	process	0.70
ferroptosis	activates	process	0.70
neurodegeneration	causes	process	0.70
OXIDATIVE STRESS	activates	phenotype	0.70
ATP	regulates	phenotype	0.65
INSULIN RESISTANCE	treats	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
FERROPTOSIS	treats	phenotype	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
OXIDATIVE STRESS	biomarker_for	phenotype	0.65
NEURONS	protects_against	cell_type	0.65
CALCIUM SIGNALING	protects_against	pathway	0.65
NEURONS	activates	cell_type	0.65
NEURONS	treats	cell_type	0.65
TAU	phosphorylates	protein	0.65
UBIQUITIN	activates	protein	0.65
ALZHEIMER'S DISEASE	degrades	disease	0.65
MICROGLIAL ACTIVATION	regulates	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
ROS	treats	phenotype	0.65
GPX4	regulates	gene	0.65
ACSL4	activates	gene	0.65
ACSL4	regulates	gene	0.65
GPX4	causes	gene	0.65
GLUTAMATE	inhibits	phenotype	0.65
HMGCR	treats	gene	0.65
FERROPTOSIS	protects_against	phenotype	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
NEURODEGENERATION	participates_in	disease	0.55
ALZHEIMER'S DISEASE	associated_with	disease	0.55
NEURODEGENERATION	implicated_in	disease	0.55
QUERCETIN	associated_with	drug	0.50
CORTEX	associated_with	brain_region	0.50

Incoming (87)

Source	Relation	Type	Str
ferroptosis	causes	process	0.95
Ferroptosis	mediates	process	0.92
ZnONPs	causes	drug	0.90
ROS	causes	process	0.90
L-Carnitine	downregulates	compound	0.90
41944914	reduces	paper	0.90
AMPK	inhibits	protein	0.90
Oxidative Stress	causes	process	0.90
GPX4	inhibits	protein	0.90
Alox12	drives	protein	0.90
Cadmium	associated_with	compound	0.90
GPX4	catalyzes	protein	0.90
GSR	inhibits	gene	0.90
NQO1	inhibits	gene	0.90
34145375	is the driver of	paper	0.90
Myelin Debris	promotes	compound	0.90
34145375	reduces	paper	0.90
Sbfi26	promotes	drug	0.90
34145375	drives	paper	0.90
Ferrostatin-1	inhibits	compound	0.90
L-Carnitine	inhibits	compound	0.85
Alox12	promotes	protein	0.85
Myelin Debris	causes	compound	0.85
Ferrous Ions	promotes	compound	0.85
ferroptosis	mediates	process	0.85
Ferroptosis	associated_with	process	0.85
Ferrous Ions	contributes_to	compound	0.85
Superoxide Anion Free Radicals	causes	compound	0.85
Lipid Antioxidants	protects_against	compound	0.85
FSP1	inhibits	protein	0.85
TP53	upstream_of	gene	0.85
Fatty Acids	contributes_to	compound	0.85
TP53	promotes	gene	0.85
Liproxstatin-1	inhibits	drug	0.85
Fatty Acid Accumulation	associated_with	phenotype	0.80
Chronic Cerebral Hypoperfusion	associated_with	condition	0.80
Endolysosomal Targeting	mediates	process	0.80
SBFI26	associated_with	chemical	0.80
Iron Imbalance	causes	process	0.80
labile iron pool	causes	pathway	0.70
Fenton chemistry	causes	mechanism	0.70
iron	causes	biomarker	0.70
NAC	prevents	drug	0.70
WHITE MATTER	causes	brain_region	0.70
ALOX15	enhances	protein	0.70
Ferroptosis	causes	pathway	0.70
iron accumulation	causes	mechanism	0.70
TH	activates	gene	0.70
SENESCENCE	regulates	phenotype	0.70
NRF2	activates	gene	0.65

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Iron-driven lipid peroxidation and GPX4 failure create a fer	0.750	neurodegeneration	What mechanisms drive the self-amplifyin
Senescence-Induced Lipid Peroxidation Spreading	0.730	neurodegeneration	Senolytic therapy for age-related neurod
APOE4 dual function: beneficial astrocyte anti-inflammatory	0.575	Alzheimer's disease	How does APOE4's beneficial immune funct

Mentioning Analyses (4)

Scientific analyses that reference this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Is ferroptosis the primary driver of motor neuron death in ALS or an epiphenomen

neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Iron Dyshomeostasis in MSA Pathogenesis Experiment	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,280,000
Peroxisomal Dysfunction Validation in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Peroxisome Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Discovery of a glycosylated colchicine derivative as a neuroprotective agent for [PMID:41455281]	["Jash M", "Gupta S", "Garg S", "Khan J"	European journal of medicinal	2026	0
The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves ca [PMID:41671579]	Wang J, Li CM, Yang B, Tantai RN, Guo HX	British journal of pharmacolog	2026	0
From association to mechanism: Prenatal PFAS Co-exposures induces fetal neural t [PMID:41485332]	Chen Y, Cheng Q, Yang C, Li S, Lin H, Li	Journal of hazardous materials	2026	0
Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses i [PMID:41540498]	Fang F, Xu Q, Shen S, Wang S, Bao C	European journal of medical re	2026	0
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis [PMID:41822239]	Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z	Food science & nutrition	2026	0
Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporo [PMID:41016294]	["Hu L", "Luo M", "Zhu X", "Wang Z", "Ya	Phytomedicine : international	2025	0
Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614]	["Jin H", "Xue B", "Chen X", "Ma T", "Ma	Environmental pollution (Barki	2025	0
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferropt [PMID:40214929]	["Zhang Y", "Tang Q", "Yao J", "Liu H",	Journal of neuroimmune pharmac	2025	0
Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-me [PMID:41080723]	["Liu Q", "Zhang J", "Yu L", "Chen Y", "	Materials today. Bio	2025	0
Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradat [PMID:39503881]	["Guo L", "Yang Y", "Ma J", "Xiao M", "C	Cell biology and toxicology	2024	0
Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST me [PMID:38906233]	["Shi Y", "Xu N", "Liu B", "Ma Y", "Fu X	Free radical biology & medicin	2024	0
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to D [PMID:37679058]	["Liu C", "Wang Y", "Zeng Y", "Kang Z",	Advanced science (Weinheim, Ba	2023	0
In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. [PMID:35384401]	["Ide K", "Souma T"]	Current protocols	2022	0
Commentary: Toward Less Traumatic, Not Just Less Invasive, Surgery [PMID:33188881]	Bremner Ross M	Seminars in Thoracic and Cardi	2021	0
En masse DNA Electroporation for in vivo Transcriptional Assay in Ascidian Embry [PMID:34692910]	Darras S	Bio-protocol	2021	0
Management of primary aldosteronism and mineralocorticoid receptor-associated hy [PMID:32424201]	["Morimoto S", "Ichihara A"]	Hypertension research : offici	2020	0

Debates (4)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

The debate highlighted compelling correlative evidence for ferroptosis markers i

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

closed · Rounds: 5 · Score: 0.59 · 2026-04-16

What are the mechanisms underlying senolytic therapy for age-related neurodegene

closed · Rounds: 4 · Score: 0.92 · 2026-04-01

Related Research

Hypotheses and analyses mentioning LIPID PEROXIDATION in their description or question text

No additional research found