| Gene Symbol | LIS1 |
| Full Name | Lissencephaly 1 |
| Chromosome | 17p13.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 46 kDa |
| UniProt ID | [P43004](https://www.uniprot.org/uniprot/P43004) |
| Ensembl ID | ENSG00000007174 |
| GeneCards | LIS1 |
| Human Protein Atlas | LIS1 |
| Neuronal progenitor positioning | Guides radial migration of neurons from ventricular zone to cortical plate |
| Leading process extension | Maintains stability of the leading process in migrating neurons |
| Nuclear translocation | Facilitates nuclear movement during somal translocation |
| Cortical layering | Ensures proper formation of cortical layers (1-6) |
| Ventricular zone | High expression in neural progenitor cells |
| Migrating neurons | Strong expression in the intermediate zone |
| Associated Diseases | AD, ADH, ALI, Als, AMI |
| Interactions | Actin, AND, CDK5, DAB1, DISC1, Dynein |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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