Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSP90B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HSP90B1 |
| Chromosome | 15q26.3 |
| Function | GRP94 (encoded by HSP90B1) is a member of the heat shock protein 90 family, distinguished by its ER-resident localization and unique client protein repertoire |
| Molecular Weight | 90 kDa |
| Pathways | Mapk |
| UniProt ID | P14625 |
| NCBI Gene ID | 27197 |
| OMIM | 611719 |
| GeneCards | HSP90B1 |
| Human Protein Atlas | HSP90B1 |
| Sensor Function | Acts as ER stress sensor |
| Chaperone Induction | Upregulated during ER stress |
| XBP1 Splicing | Facilitates XBP1 processing |
| ATF6 Activation | Interacts with ATF6 pathway |
| Associated Diseases | neurodegeneration |
| Interactions | CDK1, EGFR, ERBB2, FOXO1, GENES, GNB4 |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HSP90B1["HSP90B1"]
DDX5["DDX5"]
HSP90B1 -->|"expressed in"| DDX5
SOD2["SOD2"]
HSP90B1 -->|"expressed in"| SOD2
AKT["AKT"]
HSP90B1 -->|"expressed in"| AKT
VEGFA["VEGFA"]
HSP90B1 -->|"expressed in"| VEGFA
Akt(["Akt"])
HSP90B1 -->|"expressed in"| Akt
Pi3K(["Pi3K"])
HSP90B1 -->|"expressed in"| Pi3K
neurodegeneration["neurodegeneration"]
HSP90B1 -->|"implicated in"| neurodegeneration
HNRNPD["HNRNPD"]
HNRNPD -->|"expressed in"| HSP90B1
PI3K["PI3K"]
PI3K -->|"expressed in"| HSP90B1
style HSP90B1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Melanoma | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Colorectal Cancer | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Wnt | activates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| DDX5 | expressed_in | gene | 0.60 |
| SOD2 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| HSPA4 | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| HSP90AA1 | activates | gene | 0.60 |
| PRKACB | activates | gene | 0.60 |
| PIK3R1 | activates | gene | 0.60 |
| IGF1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| QSOX1 | activates | gene | 0.60 |
| LAMB2 | activates | gene | 0.60 |
| WNT4 | activates | gene | 0.60 |
| LGALS1 | activates | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| GNB4 | activates | gene | 0.60 |
| Akt | expressed_in | pathway | 0.60 |
| DIABETES MELLITUS | regulates | gene | 0.60 |
| Pi3K | expressed_in | pathway | 0.60 |
| GENES | activates | gene | 0.60 |
| ERBB2 | activates | gene | 0.60 |
| AXON | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HSP90B1 in their description or question text
No additional research found