| Gene Symbol | MKP3 |
| Protein Type | Phosphatase |
| Function | is a dual-specificity protein phosphatase that specifically dephosphorylates and inactivates ERK1/2 (Extracellular Signal-Regulated Kinases 1 and 2). |
| Amino Acids | 400 aa |
| GeneCards | MKP3 |
| Human Protein Atlas | MKP3 |
| D-domain (Docking motif) | The N-terminal contains a characteristic D-domain (KIM motif) that mediates specific binding to ERK1/2, ensuring substrate specificity |
| Active site pocket | The catalytic domain forms a deep pocket that accommodates the phosphorylated threonine and tyrosine residues of ERK |
| Induced fit | Substrate binding induces conformational changes that optimize catalytic efficiency |
| Pattern formation | DUSP6 regulates ERK activity gradients during embryonic development |
| Cell fate specification | Spatial control of MAPK signaling influences cell differentiation |
| Organogenesis | Critical for proper development of lung, pancreas, and other organs |
| Signal termination | Rapidly dephosphorylates ERK to limit the duration of MAPK signals |
| Cellular homeostasis | Prevents aberrant proliferation and maintains tissue architecture |
| Stress response | Modulates MAPK activation in response to growth factors and stress |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!