| Gene Symbol | DUSP6 |
| Full Name | Dual Specificity Phosphatase 6 (MKP3) |
| Chromosome | 12p13 |
| Protein Type | Phosphatase |
| Function | is a dual-specificity phosphatase that specifically dephosphorylates and inactivates ERK1/2 (Extracellular Signal-Regulated Kinases 1 and 2). |
| Primary Expression | brain regions involved in learning and memory: |
| Subcellular Localization | The protein has a classic PTP (protein tyrosine phosphatase) fold with the HCX5R active site motif essential for catalyt |
| Amino Acids | 367 aa |
| Pathways | MAPK |
| UniProt ID | [O43508](https://www.uniprot.org/uniprot/O43508) |
| Ensembl ID | ENSG00000139318 |
| OMIM | 601653 |
| GeneCards | DUSP6 |
| Human Protein Atlas | DUSP6 |
| ERK5 | Minor substrate |
| Associated Diseases | neurodegeneration |
| Interactions | ASTROCYTES, DRP1, DUSP1, ERK1, ERK2, LRRK2 |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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