| Gene Symbol | DOT1L |
| Full Name | Histone H3K79 Methyltransferase |
| Aliases | Disruptor of Telomeric Silencing 1-like |
| Protein Type | Transferase |
| Function | encodes a protein of 1,670 amino acids with methyltransferase activity that is conserved from yeast to humans [2](https://pubmed. |
| Molecular Weight | 190 kDa |
| Amino Acids | 670 aa |
| Pathways | Calcium Signaling, Epigenetic, Hedgehog, Nf-Κb, Toll-Like Receptor |
| Ensembl ID | ENSG00000100811 |
| GeneCards | DOT1L |
| Human Protein Atlas | DOT1L |
| H3K79me1 | Associated with active gene expression, enriched in gene bodies |
| H3K79me2 | Marks transcribed genes, particularly in promoter regions |
| H3K79me3 | Correlates with highly expressed genes and DNA damage response |
| Associated Diseases | AD, cancer, carcinoma, Chemoresistance, Ms, ovarian cancer |
| Interactions | App, CANCER, GSDMD, INFLAMMATION, IRF3, NLRP3 |
| KG Connections | 114 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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