gene

MATRIN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MATRIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

8Outgoing

5Incoming

0Experiments

0Debates

Summary

MATR3 Gene

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🧬 Gene Info

Gene Symbol	MATR3
Full Name	MATRIN3
Protein Family	Matrin-3 family, RNA-binding proteins
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Nuclear matrix, speckles
Molecular Weight	125 kDa
Amino Acids	847 aa
Pathways	Autophagy, Proteasome, Ubiquitin-Proteasome
UniProt ID	P43243
GeneCards	MATR3
Human Protein Atlas	MATR3
Associated Diseases	ALS
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MATRIN3 — AlphaFold P43243 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MATR3 Gene

gene · 820 words

→

MATRIN3 Protein

protein · 514 words

→

Pathway Diagram

graph TD
    MATRIN3["MATRIN3"]
    ALS["ALS"]
    MATRIN3 -->|"associated_with"| ALS
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MATRIN3 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    Aging["Aging"]
    MATRIN3 -->|"regulates"| Aging
    Proteasome["Proteasome"]
    MATRIN3 -->|"regulates"| Proteasome
    Tdp_43["Tdp-43"]
    MATRIN3 -->|"associated_with"| Tdp_43
    Autophagy["Autophagy"]
    MATRIN3 -->|"regulates"| Autophagy
    Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    MATRIN3 -->|"regulates"| Ubiquitin_Proteasome
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"regulates"| MATRIN3
    HSP90["HSP90"]
    HSP90 -->|"regulates"| MATRIN3
    FUS["FUS"]
    FUS -->|"associated_with"| MATRIN3
    DNAJC7["DNAJC7"]
    DNAJC7 -->|"regulates"| MATRIN3
    SOD1["SOD1"]
    SOD1 -->|"associated_with"| MATRIN3
    Neuron["Neuron"]
    MATRIN3 -->|"expressed_in"| Neuron
    neurodegeneration["neurodegeneration"]
    MATRIN3 -->|"implicated_in"| neurodegeneration
    style MATRIN3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Aging	regulates	disease	0.65
Proteasome	regulates	pathway	0.60
Tdp-43	associated_with	pathway	0.60
Autophagy	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
UBIQUITIN	regulates	gene	0.60
HSP90	regulates	gene	0.60
FUS	associated_with	gene	0.60
DNAJC7	regulates	gene	0.60
SOD1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MATRIN3 in their description or question text

No additional research found