| Gene Symbol | DLL4 |
| Full Name | Delta-Like 4 |
| Chromosome | 15q15.1 |
| Function | is a critical Notch ligand that plays essential roles in vascular development, blood-brain barrier formation, and neural stem cell function. |
| Primary Expression | multiple tissues with particularly important roles in: |
| Amino Acids | 685 aa |
| Pathways | Notch, Notch signaling |
| UniProt ID | [Q9NRF0](https://www.uniprot.org/uniprot/Q9NRF0) |
| Ensembl ID | ENSG00000128917 |
| GeneCards | DLL4 |
| Human Protein Atlas | DLL4 |
| Tip cell specification | DLL4-Notch signaling is critical for tip cell formation during angiogenesis |
| Iterative signaling | DLL4 can undergo regulated intramembrane proteolysis (RIP) |
| Fringe modification | DLL4-Notch interactions are modulated by glycosyltransferases |
| Associated Diseases | disease, neuroinflammation |
| Interactions | ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ASTROCYTE, ASTROCYTES, CANCER |
| KG Connections | 110 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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