Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DUOX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DUOX2 |
| Full Name | Dual Oxidase 2 |
| Chromosome | 15q21.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 175 kDa |
| Amino Acids | 548 aa |
| UniProt ID | [Q9NRD9](https://www.uniprot.org/uniprot/Q9NRD9) |
| Ensembl ID | ENSG00000140279 |
| OMIM | 607708 |
| GeneCards | DUOX2 |
| Human Protein Atlas | DUOX2 |
| Peroxidase activity | Unlike other NOX enzymes, DUOX has intrinsic peroxidase activity |
| Calcium dependence | Directly activated by calcium through EF-hand domains |
| Maturation factor requirement | Requires DUOXA2 for proper folding and trafficking |
| [Neurons](/entities/neurons) | Very low expression under normal conditions |
| Associated Diseases | neurodegeneration |
| Interactions | AND, DLL4, DNA, IL1B, IL23A, ROS |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["DUOX2"]
N1["Als"]
N0 -->|"activates"| N1
N2["Tumor"]
N0 -->|"activates"| N2
N3["Carcinoma"]
N0 -->|"activates"| N3
N4["AND"]
N0 -->|"activates"| N4
N5["ROS"]
N0 -->|"activates"| N5
N6["IL1B"]
N0 -->|"activates"| N6
N7["DLL4"]
N0 -->|"activates"| N7
N8["DNA"]
N0 -->|"activates"| N8
N9["IL23A"]
N9 -->|"activates"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene| Source | Relation | Type | Str |
|---|---|---|---|
| IL23A | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DUOX2 in their description or question text
No additional research found