Contents

DDC Protein

🔬 Protein Info

Gene Symbol	DDC
Aliases	DDCPROTEIN
Chromosome	7p12.2
Protein Type	Enzyme
Function	This is critical for PD treatment, as the efficacy of L-DOPA therapy depends on residual AADC activity in surviving nigrostriatal neurons[@lerner2020].
Primary Expression	the substantia nigra pars compacta (SNc), ventral tegmental area (VTA), locus coeruleus, and raphe nuclei—regions critical for movement control, rewar
Molecular Weight	54 kDa
Amino Acids	466 aa
Pathways	NF-kB signaling, circadian regulation, glymphatic clearance, oxidative stress response
Ensembl ID	ENSG00000132437
GeneCards	DDC
Human Protein Atlas	DDC
Molecular weight	~54 kDa
Primary structure	480 amino acids
Cofactor requirement	Pyridoxal 5'-phosphate (PLP, vitamin B6)
Associated Diseases	als, alzheimer, Alzheimer's disease, dementia, huntington, ms
Known Drugs/Compounds	levodopa
Interactions	APOE, AQP4, GBA, LRRK2, MT1, SNCA
SciDEX Hypotheses	Correcting Gut Microbial Dopamine Imbalance to Sup
KG Connections	114 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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