disease

COLORECTAL CANCER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COLORECTAL CANCER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

968Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	CGAS, CHRNA7, CYTOKINES, MLH1, TGF-BETA
KG Connections	192 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    style ENDOPLASMIC_RETICULUM fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| DENDRITIC_CELLS["DENDRITIC CELLS"]
    style DENDRITIC_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| NUCLEUS["NUCLEUS"]
    style NUCLEUS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| SQSTM1["SQSTM1"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| LC3["LC3"]
    style LC3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| P38["P38"]
    style P38 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    COLORECTAL_CANCER["COLORECTAL CANCER"] -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    style RAPAMYCIN fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    CASP3["CASP3"] -->|"activates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style CASP3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CGAS["CGAS"] -->|"activates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style CGAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BRAF["BRAF"] -.->|"inhibits"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style BRAF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    CHRNA7["CHRNA7"] -.->|"inhibits"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    style CHRNA7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style COLORECTAL_CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (335)

Target	Relation	Type	Str
Als	inhibits	disease	1.00
Immunotherapy	therapeutic_target	pathway	1.00
Metastasis	therapeutic_target	pathway	1.00
Cancer	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Metastasis	activates	pathway	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor Microenvironment	activates	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Cancer	regulates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
Cancer	causes	disease	1.00
Tumor	inhibits	disease	1.00
Autophagy	activates	pathway	1.00
Tumor Microenvironment	therapeutic_target	pathway	1.00
Cancer	inhibits	disease	1.00
Tumor	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Invasion	therapeutic_target	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Inflammation	therapeutic_target	disease	0.95
Gastric Cancer	associated_with	disease	0.95
Als	associated_with	disease	0.95
White Population	associated_with	phenotype	0.90
Invasion	activates	pathway	0.90
Glycolysis	activates	pathway	0.90
Checkpoint Inhibitor	therapeutic_target	pathway	0.90
Metastasis	inhibits	pathway	0.90
Immune Checkpoint	therapeutic_target	pathway	0.90
Wnt	activates	pathway	0.90
Angiogenesis	therapeutic_target	pathway	0.90
Mtor	activates	pathway	0.90
Cancer	treats	disease	0.85
Carcinoma	therapeutic_target	disease	0.85
Inflammatory Bowel Disease	associated_with	disease	0.85
Cancer	biomarker_for	disease	0.85
Digestive System Cancers	associated_with	disease	0.80
Ferroptosis	activates	pathway	0.80
Apoptosis	therapeutic_target	pathway	0.80
Pi3K/Akt	activates	pathway	0.80
Microbiota	activates	pathway	0.80
Nf-Κb	activates	pathway	0.80
Egfr Signaling	therapeutic_target	pathway	0.80
Angiogenesis	inhibits	pathway	0.80
Mapk	therapeutic_target	pathway	0.80

Incoming (633)

Source	Relation	Type	Str
APOPTOSIS	inhibits	gene	1.00
KRAS	activates	gene	1.00
EGFR	therapeutic_target	gene	1.00
CANCER	inhibits	gene	1.00
MYC	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
CANCER	causes	gene	1.00
Tumor	therapeutic_target	disease	1.00
GENES	therapeutic_target	gene	1.00
INFLAMMATION	associated_with	gene	1.00
CANCER	regulates	gene	1.00
DNA	activates	gene	1.00
CANCER	associated_with	gene	1.00
APOPTOSIS	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
AKT	activates	gene	1.00
Tumor	activates	disease	1.00
AUTOPHAGY	activates	gene	1.00
GENES	associated_with	gene	1.00
CANCER	activates	gene	1.00
ROS	activates	gene	1.00
CANCER	biomarker_for	gene	0.95
MTOR	therapeutic_target	protein	0.95
DNA	associated_with	gene	0.95
STAT3	inhibits	gene	0.95
PI3K	activates	gene	0.95
RAS	associated_with	gene	0.95
CANCER	treats	gene	0.95
AKT	inhibits	gene	0.95
TP53	associated_with	gene	0.95
Sijunzi Decoction	treats	drug	0.95
GENES	activates	gene	0.95
RAS	activates	gene	0.95
PI3K/Akt/mTOR	involved_in	pathway	0.95
OVERVIEW	therapeutic_target	gene	0.95
USP36	associated_with	enzyme	0.95
AKT	therapeutic_target	gene	0.95
PI3K	therapeutic_target	gene	0.95
KRAS	therapeutic_target	gene	0.95
panitumumab	treats	drug	0.93
bevacizumab	treats	drug	0.93
EGFR	therapeutic_target	protein	0.92
ABLIM1	promotes	protein	0.92
MYC	associated_with	gene	0.90
Emodin	therapeutic_target	drug	0.90
MYC	therapeutic_target	gene	0.90
Precancerous Lesion Evolution	contributes_to	process	0.90
PI3K/AKT/mTOR pathway	implicated_in	pathway	0.90
PI3K/Akt/mTOR	implicated_in	pathway	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COLORECTAL CANCER in their description or question text

No additional research found