gene 1,145 words KG: APAF1
Contents

APAF1 Gene

🧬 Gene Info
Gene SymbolAPAF1
AliasesApoptotic Protease-Activating Factor 1
Protein TypeGene
Functionis a critical regulator of the intrinsic (mitochondrial) apoptosis pathway.
Molecular Weight130 kDa
Pathwaysapoptosis
GeneCardsAPAF1
Human Protein AtlasAPAF1
Associated Diseasesneurodegenerative_diseases
InteractionsAMPK, APOPTOSIS, CALR, CANX, caspase-3, caspase-9
KG Connections61 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Hippocampus
brain · KG edge: expressed_in
blarcamesine-axon
clinical_trial · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Genes
index · KG edge: regulates

Knowledge Graph (12 edges)

STING regulates APAF1
NRF2 regulates APAF1
CYLD activates APAF1
APAF1 activates TXNIP
APAF1 regulates TBK1
APAF1 activates caspase-9
APAF1 activates caspase-3
APAF1 implicated_in neurodegenerative_diseases
APAF1 regulates CASPASE3
APAF1 regulates BECLIN1

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