concept

SYNAPSE LOSS

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SYNAPSE LOSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

3Hypotheses

1Analyses

4Outgoing

42Incoming

4Experiments

1Debates

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💡 Concept Info

Name	SYNAPSE LOSS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Complement-Mediated Synapse Loss

mechanism · 3185 words

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Pathway Diagram

graph TD
    SYNAPSE_LOSS["SYNAPSE LOSS"]
    SYNAPSE_LOSS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SYNAPSE_LOSS -->|"correlates_with"| Cognitive_Decline["Cognitive Decline"]
    C1Q["C1Q"] -->|"mediates"| SYNAPSE_LOSS
    Microglia["Microglia"] -->|"mediates"| SYNAPSE_LOSS
    Complement["Complement"] -->|"mediates"| SYNAPSE_LOSS
    GADD45G["GADD45G"] -->|"causes"| SYNAPSE_LOSS
    Inhibition_of_C1Q["Inhibition of C1Q"] -.protects against.-> SYNAPSE_LOSS
    Inhibition_of_C3["Inhibition of C3"] -.protects against.-> SYNAPSE_LOSS
    Alzheimer_s_Disease -->|"causes"| SYNAPSE_LOSS
    NPTX2["NPTX2"] -.protects against.-> SYNAPSE_LOSS

Outgoing (4)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Cognitive Decline	associated_with	phenotype	0.90
Neuroplasticity	associated_with	process	0.88
COVID-19 Neuropathologies	biomarker_for	disease	0.80

Incoming (42)

Source	Relation	Type	Str
C1Q	mediates	protein	0.95
Complement	mediates	pathway	0.95
Microglia	mediates	cell_type	0.95
Beta-Amyloid Oligomers	causes	compound	0.92
GADD45G	causes	gene	0.92
Alzheimer's Disease	causes	disease	0.90
brain-penetrant recombinant antibody	decreases	compound	0.90
CR3	involved_in	receptor	0.90
Amyloid_Beta	causes	compound	0.90
NPTX2	protects_against	protein	0.90
Microglia	promotes	cell_type	0.90
Complement-Blocking Antibody	protects_against	drug	0.90
Microglia	causes	cell_type	0.90
MICROGLIA	mediates	cell_type	0.90
NEUROINFLAMMATION	causes	process	0.90
C1Q	associated_with	protein	0.90
Inhibition of C1Q	protects_against	mechanism	0.90
Inhibition of C3	protects_against	mechanism	0.90
Minocycline	protects_against	drug	0.90
β-amyloid Oligomers	causes	compound	0.90
Brain-Penetrant Complement-Blocking Antibody	protects_against	drug	0.90
Classical Complement Cascade	drives	pathway	0.90
Classical Complement Cascade	contributes_to	pathway	0.88
Amyloid-Beta	causes	protein	0.85
Integrated Stress Response Inhibition	associated_with	process	0.85
Dark Microglia	causes	phenotype	0.85
Complement System	contributes_to	pathway	0.85
C3	promotes	protein	0.85
Neuroinflammation	causes	process	0.85
C3	involved_in	protein	0.85
TAU	implicated_in	entity	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Lipid Synthesis Inhibition	associated_with	process	0.80
Microglia	contributes_to	cell_type	0.80
Astrocytes	contributes_to	cell_type	0.80
amyloid-β	causes	protein	0.80
microglia	promotes	cell_type	0.70
BMAL1	protects_against	gene	0.70
DEPRESSION	causes	gene	0.70
C1q blockade	inhibits	drug	0.70
tau pathology	causes	process	0.70
complement activation	causes	process	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H2: Perforant Path Synapse Loss via Early Complement Cascade	0.610	neurodegeneration	Entorhinal cortex layer II vulnerability
TREM2-C1Q Competitive Binding to Prevent Complement-Mediated	0.591	neurodegeneration	Do β-amyloid plaques and neurofibrillary
H5: Complement Dysregulation Drives Synapse Loss via Senesce	0.580	neurodegeneration	Do APOE4-driven senescent astrocytes cau

Mentioning Analyses (1)

Scientific analyses that reference this entity

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
LPS-induced mouse model of depression with synaptic loss analysis	validation	depression	0.900	LPS-treated mice	proposed	N/A
Bidirectional Mendelian randomization analysis of C1Q and ischemic str	exploratory	Ischemic stroke, Atheroscleros	0.900	Human genetic association data	proposed	N/A
Bidirectional Mendelian randomization analysis of C1Q and ischemic str	exploratory	Ischemic stroke (large artery	0.900	human genetic data	proposed	N/A
C1q neutralizing antibody intervention in depression model	validation	depression	0.850	LPS-treated mice with C1q anti	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

Related Research

Hypotheses and analyses mentioning SYNAPSE LOSS in their description or question text

No additional research found