protein 626 words KG: UBIQUITIN
Contents

Ubiquitin

🔬 Protein Info
Gene SymbolUBIQUITIN
Functionis a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates.
PathwaysAdaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy
GeneCardsUBIQUITIN
Human Protein AtlasUBIQUITIN
Associated DiseasesAging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsproteolysis-targeting chimeras, RAPAMYCIN
InteractionsABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1
KG Connections3814 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (78)

The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
← Prevpg 4/4

Related Analyses (25)

Quantitative proteomics of the aging synapse in early Alzhei
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (8)

TRIM21-mediated K63-linked ubiquitination of G3BP1
exploratory · proposed · Score: 0.95
TRIM21 E3 ubiquitin ligase screen for stress granule regulat
exploratory · proposed · Score: 0.90
Hyperoside-ACAT1 direct binding interaction studies
exploratory · proposed · Score: 0.85
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (9)

ABCD3 Gene
gene · KG edge: interacts_with
ABIN1 (TNIP1) Gene
gene · KG edge: regulates
ACE Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: regulates
ACTB Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PINK1 phosphorylates UBIQUITIN
CTSD activates UBIQUITIN
DDIT3 activates UBIQUITIN
DISC1 activates UBIQUITIN
TSC1 regulates UBIQUITIN
MTOR regulates UBIQUITIN
UBIQUITIN regulates ATF4
UBIQUITIN regulates TSC2
UBIQUITIN interacts_with DDB1
UBIQUITIN interacts_with ATG12

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