protein 626 words KG: UBIQUITIN
Contents

Ubiquitin

🔬 Protein Info
Gene SymbolUBIQUITIN
Functionis a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates.
PathwaysAdaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy
GeneCardsUBIQUITIN
Human Protein AtlasUBIQUITIN
Associated DiseasesAging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsproteolysis-targeting chimeras, RAPAMYCIN
InteractionsABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1
KG Connections3814 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (78)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
← Prevpg 3/4Next →

Related Analyses (25)

Quantitative proteomics of the aging synapse in early Alzhei
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (8)

TRIM21-mediated K63-linked ubiquitination of G3BP1
exploratory · proposed · Score: 0.95
TRIM21 E3 ubiquitin ligase screen for stress granule regulat
exploratory · proposed · Score: 0.90
Hyperoside-ACAT1 direct binding interaction studies
exploratory · proposed · Score: 0.85
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (9)

ABCD3 Gene
gene · KG edge: interacts_with
ABIN1 (TNIP1) Gene
gene · KG edge: regulates
ACE Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: regulates
ACTB Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PINK1 phosphorylates UBIQUITIN
CTSD activates UBIQUITIN
DDIT3 activates UBIQUITIN
DISC1 activates UBIQUITIN
TSC1 regulates UBIQUITIN
MTOR regulates UBIQUITIN
UBIQUITIN regulates ATF4
UBIQUITIN regulates TSC2
UBIQUITIN interacts_with DDB1
UBIQUITIN interacts_with ATG12

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