protein 626 words KG: UBIQUITIN
Contents

Ubiquitin

🔬 Protein Info
Gene SymbolUBIQUITIN
Functionis a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates.
PathwaysAdaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy
GeneCardsUBIQUITIN
Human Protein AtlasUBIQUITIN
Associated DiseasesAging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsproteolysis-targeting chimeras, RAPAMYCIN
InteractionsABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1
KG Connections3814 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (78)

APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
← Prevpg 2/4Next →

Related Analyses (25)

Quantitative proteomics of the aging synapse in early Alzhei
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (8)

TRIM21-mediated K63-linked ubiquitination of G3BP1
exploratory · proposed · Score: 0.95
TRIM21 E3 ubiquitin ligase screen for stress granule regulat
exploratory · proposed · Score: 0.90
Hyperoside-ACAT1 direct binding interaction studies
exploratory · proposed · Score: 0.85
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (9)

ABCD3 Gene
gene · KG edge: interacts_with
ABIN1 (TNIP1) Gene
gene · KG edge: regulates
ACE Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: regulates
ACTB Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PINK1 phosphorylates UBIQUITIN
CTSD activates UBIQUITIN
DDIT3 activates UBIQUITIN
DISC1 activates UBIQUITIN
TSC1 regulates UBIQUITIN
MTOR regulates UBIQUITIN
UBIQUITIN regulates ATF4
UBIQUITIN regulates TSC2
UBIQUITIN interacts_with DDB1
UBIQUITIN interacts_with ATG12

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