protein 626 words KG: UBIQUITIN
Contents

Ubiquitin

🔬 Protein Info
Gene SymbolUBIQUITIN
Functionis a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates.
PathwaysAdaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy
GeneCardsUBIQUITIN
Human Protein AtlasUBIQUITIN
Associated DiseasesAging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compoundsproteolysis-targeting chimeras, RAPAMYCIN
InteractionsABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1
KG Connections3814 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (78)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Flotillin-1 Stabilization Compounds
Score: 0.68
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Arginine Methylation Enhancement Therapy
Score: 0.65
Nucleolar Stress Response Normalization
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Lysosomal Membrane Repair Enhancement
Score: 0.54
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.92
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Related Analyses (25)

Quantitative proteomics of the aging synapse in early Alzhei
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (8)

TRIM21-mediated K63-linked ubiquitination of G3BP1
exploratory · proposed · Score: 0.95
TRIM21 E3 ubiquitin ligase screen for stress granule regulat
exploratory · proposed · Score: 0.90
Hyperoside-ACAT1 direct binding interaction studies
exploratory · proposed · Score: 0.85
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (9)

ABCD3 Gene
gene · KG edge: interacts_with
ABIN1 (TNIP1) Gene
gene · KG edge: regulates
ACE Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: regulates
ACTB Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

PINK1 phosphorylates UBIQUITIN
CTSD activates UBIQUITIN
DDIT3 activates UBIQUITIN
DISC1 activates UBIQUITIN
TSC1 regulates UBIQUITIN
MTOR regulates UBIQUITIN
UBIQUITIN regulates ATF4
UBIQUITIN regulates TSC2
UBIQUITIN interacts_with DDB1
UBIQUITIN interacts_with ATG12

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