protein 1,222 words KG: MET
Contents

MET Protein

🔬 Protein Info
Gene SymbolMET
AliasesPage for MET, c-Met
Chromosome7q31.2
Protein TypeReceptor
Functionis a receptor tyrosine kinase (RTK) that plays crucial roles in embryonic development, tissue regeneration, and adult tissue homeostasis.
Molecular Weight140 kDa
Amino Acids1390 aa
Exons21
PathwaysKey Effectors
GeneCardsMET
Human Protein AtlasMET
Associated DiseasesAD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compoundsmetformin, PLB-1001, resveratrol
InteractionsAKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections636 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (24)

The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Arginine Methylation Enhancement Therapy
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Sphingolipid Metabolism Reprogramming
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Aquaporin-4 Polarization Rescue
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
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Related Analyses (11)

Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40

Key Papers (1)

Using dynamic monitoring of choices to predict and understand risk pre
Proceedings of the National Ac 2021

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 7 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 7 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 7 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 7 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 7 hypotheses

Knowledge Graph (12 edges)

IDH1 therapeutic_target MET
VEGFA therapeutic_target MET
MDM4 therapeutic_target MET
APOB inhibits MET
SF3B1 therapeutic_target MET
MET therapeutic_target SMARCA4
MET therapeutic_target TERT
MET therapeutic_target JUN
MET therapeutic_target EEF1A1
MET therapeutic_target MCL1

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