protein 937 words KG: MAP1B
Contents

MAP1B Protein

🔬 Protein Info
Gene SymbolMAP1B
Full NameMicrotubule-Associated Protein 1B
Chromosome5q13.2
Protein FamilyMAP1 family
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressiondeveloping neurons
Subcellular LocalizationAxons, growth cones, synaptic terminals, dendrites
Molecular Weight~300 kDa (heavy chain), ~30 kDa (light chains)
Amino Acids2700 aa
PathwaysAutophagy, NF-kB signaling
UniProt IDP46821
GeneCardsMAP1B
Human Protein AtlasMAP1B
SubunitsMAP1B heavy chain (MAP1B-HC) and light chains (MAP1B-LC1, LC2, LC3)
Associated DiseasesAD, ALI, Als, AMI, NMO, RA
InteractionsAND, AUTOPHAGY, LC3, MAP1A, MAP2, MAP6
KG Connections61 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

blarcamesine-axon
clinical_trial · KG edge: transports
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
GABARAP Gene
gene · KG edge: regulates
HSP90AA1 Gene
gene · KG edge: associated_with
MAP1LC3A Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

MAP2 interacts_with MAP1B
MAP1B interacts_with MAP6
MAP1B interacts_with MAP2
MAP1B regulates GABARAP
MAP1B implicated_in NMO
MAP1B interacts_with UBIQUITIN
MAP1B associated_with NBR1
MAP1B interacts_with LC3
MAP1B interacts_with TAU
MAP6 interacts_with MAP1B

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