Contents

MAP6 Gene

🧬 Gene Info

Gene Symbol	MAP6
Chromosome	11q13.2
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Unlike other MAPs that promote microtubule assembly, MAP6 stabilizes microtubules by preventing depolymerization and protecting them from disassembly under stress conditions[@takemura2018].
Mechanism of Action	Drugs targeting MAP6 would stabilize microtubules through direct binding or modulation of MAP6's stabilizing activity, thereby promoting neuronal cytoskeletal integrity and synaptic function. This stabilization could enhance axonal transport, prevent neuronal degeneration, and support cognitive and synaptic plasticity in neurodegenerative conditions.
Primary Expression	neurons throughout development and in adulthood
Subcellular Localization	4. Proteolytic cleavage: Specific cleavage generates functional fragments
Druggability	Undruggable (0.21)
Clinical Stage	Phase II
Molecular Weight	85 kDa
Amino Acids	789 aa
Exons	14
Pathways	Tau-Independent Microtubule Stabilization via MAP6
UniProt ID	Q96JE9
GeneCards	MAP6
Human Protein Atlas	MAP6
Associated Diseases	AD, ALI, Als, AMI, neurodegeneration
Known Drugs/Compounds	Paclitaxel (Taxol), Ixabepilone (Ixempra), MAP6-derived peptide stabilizers, Microtubule-associated protein kinase inhibitors
Interactions	C1Q, CDK5, CRMP1, HDAC, MAP1A, MAP1B
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	Tau-Independent Microtubule Stabilization via MAP6
KG Connections	201 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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