| Gene Symbol | MACF1 |
| Full Name | Microtubule-actin crosslinking factor 1 |
| Aliases | ACF7, Spectraplakin |
| Chromosome | 9p21.3 |
| Function | is a massive ~620 kDa cytoskeletal protein that serves as a critical bridge between actin microfilaments and microtubules [1](https://pubmed. |
| Primary Expression | Brain (cortex, hippocampus, cerebellum), lung, kidney, testis |
| Molecular Weight | 620 kDa |
| Amino Acids | 5434 aa |
| Exons | 93 |
| Pathways | Epithelial-Mesenchymal Transition, Metastasis |
| UniProt ID | Q9UPV3 |
| NCBI Gene ID | 23499 |
| Ensembl ID | ENSG00000127603 |
| OMIM | 608271 |
| GeneCards | MACF1 |
| Human Protein Atlas | MACF1 |
| Associated Diseases | Cancer, Diabetes |
| Interactions | APOPTOSIS, NRCAM, Raf |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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